A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

Ganna Lyubartseva; Mark A. Lovell

doi:10.1002/biof.199

A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

Ganna Lyubartseva, Mark A. Lovell

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (Aβ) peptide generation and aggregation.

Original language	English
Pages (from-to)	98-106
Number of pages	9
Journal	BioFactors
Volume	38
Issue number	2
DOIs	https://doi.org/10.1002/biof.199
State	Published - Mar 2012

Keywords

Alzheimer's disease
Amyloid beta peptide
Mild clinical impairment
Preclinical Alzheimer's disease
Zinc
Zinc transporter proteins

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Clinical Biochemistry

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10.1002/biof.199

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abstract = "Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (Aβ) peptide generation and aggregation.",

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AB - Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (Aβ) peptide generation and aggregation.

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KW - Amyloid beta peptide

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KW - Preclinical Alzheimer's disease

KW - Zinc

KW - Zinc transporter proteins

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A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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