A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis

Octavio A. Gonzalez; Vanessa Euzebio-Alves; Yelena Alimova; Ahmad Al-Attar; J. L. Ebersole

doi:10.1007/978-3-030-28524-1_7

A Potential Role of Phospholipase 2 Group IIA (PLA₂-IIA) in P. gingivalis-Induced Oral Dysbiosis

Octavio A. Gonzalez, Vanessa Euzebio-Alves, Yelena Alimova, Ahmad Al-Attar, J. L. Ebersole

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA₂-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA₂-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA₂-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA₂-IIA as well as its role in other chronic inflammatory diseases.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Pages	79-95
Number of pages	17
DOIs	https://doi.org/10.1007/978-3-030-28524-1_7
State	Published - 2019

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1197
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Funding

Findings reported in this review were funded by NIH/NIDCR grant DE024804, NIH/ NIGMS P20GM103538 and College of Dentistry University of Kentucky. We thank Drs. Yongzheng Wu and Lhousseine Touqi from Institute Pasteur for kindly sharing the hPLA2-IIA-Tg mice as well as Drs. Jorge Frias (U. of Florida) and Sreenatha Kirakodu (U. of Kentucky) for their support in oral microbiome preliminary analysis. We also are grateful to Dr. Brittany Camenisch and Division of Periodontology for supporting the ongoing preliminary clinical study in salivary PLA2-IIA levels.

Funders	Funder number
University of Kentucky College of Dentistry Division of Periodontology
NIH/NIDCR	DE024804, NIH/ NIGMS P20GM103538
University of Kentucky College of Dentistry	Kentucky

Keywords

Oral dysbiosis
Oral epithelial cells
P. gingivalis
PLA-IIA
Periodontal disease

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-28524-1_7

Cite this

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abstract = "Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA2-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA2-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA2-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA2-IIA as well as its role in other chronic inflammatory diseases.",

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A Potential Role of Phospholipase 2 Group IIA (PLA₂-IIA) in P. gingivalis-Induced Oral Dysbiosis. / Gonzalez, Octavio A.; Euzebio-Alves, Vanessa; Alimova, Yelena et al.
Advances in Experimental Medicine and Biology. 2019. p. 79-95 (Advances in Experimental Medicine and Biology; Vol. 1197).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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