Abstract
Objective: As therapeutic options are rapidly expanding to treat pain of discogenic and vertebrogenic origin, it is important for the clinician to have an evidence-based understanding of the latest information regarding the normal and pathological anatomy of the intervertebral disc as well as imaging characteristics and treatment strategies. The American Society of Pain and Neuroscience (ASPN) commissioned the DISC project to inform and update the interventional spine community about anterior column pain syndromes. Methods: Using established literature review methods a clinical oversight group was convened to create an outline covering topics that will be key to meeting the objectives delineated by the ASPN scientific and guidelines leadership. This oversight group, using the created outline, selected key opinion leaders and experts to assemble the latest information on anterior column and intervertebral disc anatomy and treatment to serve as a living document that can be continuously updated to drive best practices and innovation. Results: A review of normal and pathological anatomy, a comprehensive understanding of biophysics applied to the anterior spinal column, and understanding of the current state of practice with regard to imaging, diagnostic classification systems and treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 6651-6698 |
| Number of pages | 48 |
| Journal | Journal of Pain Research |
| Volume | 18 |
| DOIs | |
| State | Published - 2025 |
Bibliographical note
Publisher Copyright:© 2025 Grider et al.
Funding
The following Authors have no relevant conflicts of interest for this work: Jacob Fleming, Mark Malinowski, Rose Garcia, Anuj Shah, Hamzah Ramawad, Iden Cowan, Kristin Jarzombek, Kas Amirdelfin, Marcin Karcz, Kas, Brian Durkin, Matthew Green. Jay Grider: Original Shares in Spinal Simplicity and on original Medical Advisory for Interalink Spine purchased by Spinal Simplicity. Timothy Deer: Relevant conflicts: Consultant for Vivex. Consultant for Spinal Simplicity. Douglas Beall: Relevant conflicts: Consultant/Receipt of grants/research supports: ReGelTec, Orthoson, Vivex, Discgenics, Mesoblast, Discure, Tissue Tech, Smart Soft, Medtronic, Merit Medical, Johnson & Johnson, IZI, Techlamed, Peterson Enterprises, Medical Metrics, Avanos, Boston Scientific, Simplify Medical, Stryker, Lenoss Medical, Piramal, Nanofuse, Spinal Simplicity, Spark Biomedical, Bronx Medical, Smart Soft, RayShield, Stayble, Thermaquil, Vivex, Stratus Medical, Genesys, Abbott, Eliquence, SetBone Medical, Amber Implants, Cerapedics, Neurovasis, Spine Biopharma; Receipt of honoraria or consultation fees: ReGelTec, Vivex, Mesoblast, Discure; Research Funding: ReGelTec, Orthoson, Vivex, Discgenics, Mesoblast, Discure, Tissue Tech, Spine Biopharma, Kolon TissueGene. Melissa Murphy: Medtronic: speaking, consulting, research. Pacira Biosciences: speaking, consulting, research, Nervonik: advisory board, stockholders. Steven Falowski: Consultant-Abbott Shiratronics, Medtronic Saluda CornerLoc Equity-BackStop, Neural, SurgenTec, SynerFuse, Aurora Spine, Thermaquil, SPR Therapeutics, Saluda CornerLoc, PainTeq, Celeri. Nasir Khatri: Abbott, Brixton Biosciences (research grant only) Nalu (research grant only), Nevro/Globus, Saluda, Spinal Simplicity, SPR Therapeutics, WISE Srl. Mateusz Graca: Consultant for ViaDIsc and VIVEX Biologics. Jordan Tate: ReGeltec Research Grant, Saluda- Consultant, Research Grant, Commercial Advisory Board, Medtronic- Consultant, Stimwave- Consultant, Vertos- Consultant, Nevro- Consultant, Research Grants, Commercial Advisory Board, Styker- Consultant, Lab Faculty, Curonix- Consultant, Lab Faculty, Mainstay- Consultant, Research Grant, Lab Faculty, Vivex- Consultant, Research Grants, Abbott -Consultant, Lab Faculty, PainTeq -Consultant, Commercial Advisory Board. Usman Latif: is a consultant for Abbott, Brixton Biosciences, InFormed Consent, Nalu, Nevro, Saluda Medical, Spinal Simplicity, SPR, Stryker, Vertex Pharmaceuticals, Vertos Medical, Vivex Biologics, and WISE; an advisory board member for Abbott, InFormed Consent, Nalu, Nevro, Saluda Medical, Spinal Simplicity, Vertos Medical, and Vivex Biologics; has funded research with Mainstay Medical, Nalu, Spinal Simplicity, and Vivex Biologics; and has stock or stock options with InFormed Consent and Spinal Simplicity. Chau Vu: is a consultant for Saluda Medical and PainTEQ. Christopher Mallard: Medtronic grant recipient paid to the university and consulting fees for Johnson & Johnson. Kaku Barkoh: XoBiologix, Abbott, Spinal Simplicity, Intrinsic Therapeutics, Kuros Biosciences. Anne Christopher: Paid consultant Abbott, SI Bone, Boston Scientific. Michael Harned: Medtronic grant recipient paid to university. Raj Patel: is a consultant for Vivex. Tim Davis: consulting fees from Abbott, Boston Scientific, Biotronik; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Abbott, Boston Scientific, Biotronik, research support from Vivex, Mesoblast, Spine Biopharma, Biorestorative Therapies, and SI BONE, outside the submitted work. Olivier Clerk-Lamalice: reports personal fees from Stryker, Medical Metrics, stocks/options from Regeltec, SpinaFx, and Beam Medical, outside the submitted work. Brian Durkin: reports personal fees from Boston Scientific, outside the submitted work. Dagmar Gross: reports personal fees from ReGelTec, outside the submitted work. Mark Malinowski: reports personal fees from Abbott, Biotronik and Nevro, outside the submitted work. Tom Hedman: an employee of Spinal Simplicity. He also reports intralink formulation patent issued to Spinal Simplicity LLC. Michael Dorsi: Biotronik, Abbott, Globus, Saluda, Painteq, Ferring, Stryker. Dawood Sayed: consultant for PainTeq, Abbott, Mainstay, Saluda and Surgentec. The authors report no other conflicts of interest in this work. Financial support for this work was provided, in part, by Vivex Biologics (Miami, FL, USA). The authors appreciate the thorough review by Jon E. Block, Ph.D. and the manuscript preparation by Malahki Thorn. Hamzah A. Ramawad M.D contributed the original illustrations in .
| Funders |
|---|
| Brixton Biosciences |
| Nevro Corporation |
| Globus |
| Vivex Biologics |
| Abbott Diagnostics |
Keywords
- ASPN
- anatomy
- anterior column pain
- disc
- functional spinal unit
- imaging
- intradiscal
- pathology
- regenerative medicine
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Fingerprint
Dive into the research topics of 'A Primer on Anatomy, Biophysics, Pathology, Imaging and Treatment of the Intervertebral Disc and the Anterior Spinal Column: The Discogenic, Intervertebral, Spinal Column (DISC) ASPN Workgroup'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver