A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis

Tyler Stevens, Darwin L. Conwell, Gregory Zuccaro, Frederick Van Lente, Rocio Lopez, Edward Purich, Seymour Fein

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78 Citations (SciVal)

Abstract

Background: Direct pancreatic function tests (PFT) are conventionally performed with use of double-lumen "Dreiling" collection tubes. We have developed an endoscopic collection method (ePFT) that eases the performance of these tests. Objective: Our aim was to compare the bicarbonate results obtained from the secretin ePFT and Dreiling PFT methods in patients evaluated for chronic pancreatitis. Design: A prospective crossover design was used to compare the PFT methods. Setting: Tertiary care referral center. Patients and Interventions: Twenty-four patients undergoing an evaluation for chronic pancreatitis underwent the secretin-stimulated ePFT and Dreiling PFT methods on separate days. Main Outcome Measurements: Duodenal fluid bicarbonate concentrations and estimated bicarbonate outputs were compared. Results: The mean difference in peak bicarbonate concentration (Dreiling PFT minus ePFT) was 7 mEq/L (SD 20) and not statistically significant (P = .11). A good correlation in peak bicarbonate concentrations (r = 0.74, 95% CI, 0.48-0.88) and estimated bicarbonate output (r = 0.78, 95% CI, 0.54-0.90) was observed between the two PFT methods. Limitation: The sensitivities and specificities of the secretin ePFT and Dreiling PFT could not be compared because of the lack of a histologic gold standard. Conclusion: The secretin ePFT yields results similar to those of the Dreiling PFT in patients evaluated for chronic pancreatitis.

Original languageEnglish
Pages (from-to)458-466
Number of pages9
JournalGastrointestinal Endoscopy
Volume67
Issue number3
DOIs
StatePublished - Mar 2008

Bibliographical note

Funding Information:
The following authors report that they have no disclosures relevant to this publication: T. Stevens, D. L. Conwell, G. Zuccaro Jr., F. Van Lente, R. Lopez. The following authors have disclosed actual or potential conflicts: E. Purich is president and CEO and S. Fein is medical director of ChiRhoClin, Inc, a manufacturer of synthetic secretin. Support was provided by an unrestricted education and research grant from Solvay Pharmaceuticals (Marietta, Georgia, USA) .

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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