A protein nanocarrier from charge-conversion polymer in response to endosomal pH

Yan Lee, Shigeto Fukushima, Younsoo Bae, Shigehiro Hiki, Takehiko Ishii, Kazunori Kataoka

Research output: Contribution to journalArticlepeer-review

372 Scopus citations

Abstract

A new type of polyion complex (PIC) micelle was prepared from lysozyme and the block copolymer, PEG-pAsp(EDA-Cit), that can switch the charge from anionic to cationic at the endosomal pH. The charge-conversion was due to the degradation of the citraconic amide side chain at pH 5.5. This abrupt charge-conversion can make the PIC micelles promptly release the internal protein in response to the endosomal pH. This pH-sensitive charge-conversion polymer is promising for the future design of nanocarriers for early endosomal release.

Original languageEnglish
Pages (from-to)5362-5363
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number17
DOIs
StatePublished - May 2 2007

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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