HIV-associated neurocognitive disorder (HAND) is experienced by 30% to 50% of people living with HIV (PLWH), potentially affecting their quality of life (QoL). In the Training on Purpose Study, we investigated whether targeted cognitive training can improve QoL in PLWH with HAND. Using a two-group experimental design, we randomized 109 adults with HAND to either (a) the Individualized-Targeted Cognitive Training group or (b) a no-contact control group. Those in the training group were assigned 10 hr of cognitive training per two selected cognitive domains (20 hr total) for which impairment was observed. Overall, two patterns emerged. First, significant improvements in measures of everyday cognitive complaints, depression, and mental health were consistently observed after the completion of many cognitive training protocols. Second, immediate and delayed spatial learning and memory training resulted in more significant indicators of QoL improvements compared with the other cognitive domain trainings. The findings suggest that some types of cognitive training may have advantages over others in improving aspects of QoL.
|Number of pages||16|
|Journal||Journal of the Association of Nurses in AIDS Care|
|State||Published - May 1 2022|
Bibliographical noteFunding Information:
This study was funded by an NIH/NINR R21-award (1R21NR016632-01; ClinicalTrials.gov ; NCT03122288; PI: D. Vance) titled “Individualized-Targeted Cognitive Training in Older Adults with HAND” and an NIH/NIA P30-award (Edward R. Roybal Center for Translational Research in Aging and Mobility; P30 AG022838; PI: K. K. Ball). The authors thank their research team, especially Brittany Bradley, Delaney Diehl, Shyla Hossain, Michael Jenson, Peggy McKie, Josiah Robinson, Frida Tende, and Tess Walker.
© 2022 Elsevier USA. All rights reserved.
- cognitive complaints
- cognitive training
- HIV-associated neurocognitive disorder
- quality of life
- speed of processing
ASJC Scopus subject areas
- Advanced and Specialized Nursing