A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States

David E. Vance, Caitlin N. Pope, Pariya L. Fazeli, Andres Azuero, Jennifer S. Frank, Virginia G. Wadley, James L. Raper, Jun Y. Byun, Karlene K. Ball

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

HIV-associated neurocognitive disorder (HAND) is experienced by 30% to 50% of people living with HIV (PLWH), potentially affecting their quality of life (QoL). In the Training on Purpose Study, we investigated whether targeted cognitive training can improve QoL in PLWH with HAND. Using a two-group experimental design, we randomized 109 adults with HAND to either (a) the Individualized-Targeted Cognitive Training group or (b) a no-contact control group. Those in the training group were assigned 10 hr of cognitive training per two selected cognitive domains (20 hr total) for which impairment was observed. Overall, two patterns emerged. First, significant improvements in measures of everyday cognitive complaints, depression, and mental health were consistently observed after the completion of many cognitive training protocols. Second, immediate and delayed spatial learning and memory training resulted in more significant indicators of QoL improvements compared with the other cognitive domain trainings. The findings suggest that some types of cognitive training may have advantages over others in improving aspects of QoL.

Original languageEnglish
Pages (from-to)295-310
Number of pages16
JournalJournal of the Association of Nurses in AIDS Care
Volume33
Issue number3
DOIs
StatePublished - May 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier USA. All rights reserved.

Keywords

  • HIV-associated neurocognitive disorder
  • cognitive complaints
  • cognitive training
  • neuroplasticity
  • quality of life
  • speed of processing

ASJC Scopus subject areas

  • Advanced and Specialized Nursing

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