A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States

David E. Vance; Caitlin N. Pope; Pariya L. Fazeli; Andres Azuero; Jennifer S. Frank; Virginia G. Wadley; James L. Raper; Jun Y. Byun; Karlene K. Ball

doi:10.1097/JNC.0000000000000316

A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States

David E. Vance, Caitlin N. Pope, Pariya L. Fazeli, Andres Azuero, Jennifer S. Frank, Virginia G. Wadley, James L. Raper, Jun Y. Byun, Karlene K. Ball

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

HIV-associated neurocognitive disorder (HAND) is experienced by 30% to 50% of people living with HIV (PLWH), potentially affecting their quality of life (QoL). In the Training on Purpose Study, we investigated whether targeted cognitive training can improve QoL in PLWH with HAND. Using a two-group experimental design, we randomized 109 adults with HAND to either (a) the Individualized-Targeted Cognitive Training group or (b) a no-contact control group. Those in the training group were assigned 10 hr of cognitive training per two selected cognitive domains (20 hr total) for which impairment was observed. Overall, two patterns emerged. First, significant improvements in measures of everyday cognitive complaints, depression, and mental health were consistently observed after the completion of many cognitive training protocols. Second, immediate and delayed spatial learning and memory training resulted in more significant indicators of QoL improvements compared with the other cognitive domain trainings. The findings suggest that some types of cognitive training may have advantages over others in improving aspects of QoL.

Original language	English
Pages (from-to)	295-310
Number of pages	16
Journal	Journal of the Association of Nurses in AIDS Care
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/JNC.0000000000000316
State	Published - May 1 2022

Bibliographical note

Funding Information:
This study was funded by an NIH/NINR R21-award (1R21NR016632-01; ClinicalTrials.gov ; NCT03122288; PI: D. Vance) titled “Individualized-Targeted Cognitive Training in Older Adults with HAND” and an NIH/NIA P30-award (Edward R. Roybal Center for Translational Research in Aging and Mobility; P30 AG022838; PI: K. K. Ball). The authors thank their research team, especially Brittany Bradley, Delaney Diehl, Shyla Hossain, Michael Jenson, Peggy McKie, Josiah Robinson, Frida Tende, and Tess Walker.

Publisher Copyright:
© 2022 Elsevier USA. All rights reserved.

Keywords

cognitive complaints
cognitive training
HIV-associated neurocognitive disorder
neuroplasticity
quality of life
speed of processing

ASJC Scopus subject areas

Advanced and Specialized Nursing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JNC.0000000000000316

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Vance, D. E., Pope, C. N., Fazeli, P. L., Azuero, A., Frank, J. S., Wadley, V. G., Raper, J. L., Byun, J. Y., & Ball, K. K. (2022). A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States. Journal of the Association of Nurses in AIDS Care, 33(3), 295-310. https://doi.org/10.1097/JNC.0000000000000316

Vance, David E. ; Pope, Caitlin N. ; Fazeli, Pariya L. et al. / A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States. In: Journal of the Association of Nurses in AIDS Care. 2022 ; Vol. 33, No. 3. pp. 295-310.

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title = "A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States",

abstract = "HIV-associated neurocognitive disorder (HAND) is experienced by 30% to 50% of people living with HIV (PLWH), potentially affecting their quality of life (QoL). In the Training on Purpose Study, we investigated whether targeted cognitive training can improve QoL in PLWH with HAND. Using a two-group experimental design, we randomized 109 adults with HAND to either (a) the Individualized-Targeted Cognitive Training group or (b) a no-contact control group. Those in the training group were assigned 10 hr of cognitive training per two selected cognitive domains (20 hr total) for which impairment was observed. Overall, two patterns emerged. First, significant improvements in measures of everyday cognitive complaints, depression, and mental health were consistently observed after the completion of many cognitive training protocols. Second, immediate and delayed spatial learning and memory training resulted in more significant indicators of QoL improvements compared with the other cognitive domain trainings. The findings suggest that some types of cognitive training may have advantages over others in improving aspects of QoL.",

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note = "Funding Information: This study was funded by an NIH/NINR R21-award (1R21NR016632-01; ClinicalTrials.gov ; NCT03122288; PI: D. Vance) titled “Individualized-Targeted Cognitive Training in Older Adults with HAND” and an NIH/NIA P30-award (Edward R. Roybal Center for Translational Research in Aging and Mobility; P30 AG022838; PI: K. K. Ball). The authors thank their research team, especially Brittany Bradley, Delaney Diehl, Shyla Hossain, Michael Jenson, Peggy McKie, Josiah Robinson, Frida Tende, and Tess Walker. Publisher Copyright: {\textcopyright} 2022 Elsevier USA. All rights reserved.",

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Vance, DE, Pope, CN, Fazeli, PL, Azuero, A, Frank, JS, Wadley, VG, Raper, JL, Byun, JY & Ball, KK 2022, 'A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States', Journal of the Association of Nurses in AIDS Care, vol. 33, no. 3, pp. 295-310. https://doi.org/10.1097/JNC.0000000000000316

A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States. / Vance, David E.; Pope, Caitlin N.; Fazeli, Pariya L. et al.
In: Journal of the Association of Nurses in AIDS Care, Vol. 33, No. 3, 01.05.2022, p. 295-310.

Research output: Contribution to journal › Article › peer-review

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AU - Pope, Caitlin N.

AU - Fazeli, Pariya L.

AU - Azuero, Andres

AU - Frank, Jennifer S.

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AU - Raper, James L.

AU - Byun, Jun Y.

AU - Ball, Karlene K.

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Vance DE, Pope CN, Fazeli PL, Azuero A, Frank JS, Wadley VG et al. A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States. Journal of the Association of Nurses in AIDS Care. 2022 May 1;33(3):295-310. doi: 10.1097/JNC.0000000000000316

A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Fingerprint

Cite this