A remarkable rodent: Regeneration and reproduction in spiny mice (Acomys)

Ashley W. Seifert; Peter Temple-Smith

doi:10.1016/bs.ctdb.2021.12.017

A remarkable rodent: Regeneration and reproduction in spiny mice (Acomys)

Ashley W. Seifert, Peter Temple-Smith

Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Although certain organisms are chosen and employed to better understand a specific problem in biology (so-called model organisms), sometimes an animal model reveals its' biomedical importance by happenstance. In many ways, the advent of spiny mice (Acomys) as an emerging model to study regeneration and menstruation stands as a case study in scientific pseudoserendipity (Diaz de Chumaceiro, 1995). As we recount in this chapter, the discovery of these phenotypes, while not entirely accidental, was nonetheless unexpected. In addition to recounting how we uncovered these unusual mammalian traits, we outline recent work by our groups and others that has begun to outline the cellular and genetic mechanisms underlying bonafide mammalian tissue regeneration and a human-like mode of reproduction in spiny mice.

Original language	English
Title of host publication	Emerging Model Systems in Developmental Biology
Editors	Bob Goldstein, Mansi Srivastava
Pages	659-707
Number of pages	49
DOIs	https://doi.org/10.1016/bs.ctdb.2021.12.017
State	Published - Jan 2022

Publication series

Name	Current Topics in Developmental Biology
Volume	147
ISSN (Print)	0070-2153

Bibliographical note

Funding Information:
We would like to acknowledge those researchers that have pursued work with spiny mice in the past, often at great challenge. We would also like to thank the growing community of spiny mouse researchers that are committed to open science and that generously share information with each other about ongoing and future projects that facilitate our general understanding about these extraordinary rodents. Beyond those named in this chapter, Dr. Seifert would like to acknowledge the tireless work of several Kenyan field assistants, namely, James Ekiru Erkaran who was instrumental in trapping and site scouting in the early development of the regenerative biology work. Also, Stanley Marete in the Department of Veterinary Anatomy and Physiology at the University of Nairobi who has maintained ongoing colonies of A. kempi and A. percivali and the staff and scientists at Mpala Research Centre. Greg Schultz for his mentorship in all things wound healing. Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society. Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology.

Funding Information:
Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology.

Funding Information:
Beyond those named in this chapter, Dr. Seifert would like to acknowledge the tireless work of several Kenyan field assistants, namely, James Ekiru Erkaran who was instrumental in trapping and site scouting in the early development of the regenerative biology work. Also, Stanley Marete in the Department of Veterinary Anatomy and Physiology at the University of Nairobi who has maintained ongoing colonies of A. kempi and A. percivali and the staff and scientists at Mpala Research Centre. Greg Schultz for his mentorship in all things wound healing. Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society.

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

Acomys
Ear pinna
Endometrium
Menstruation
Regeneration
Reproduction
Skin
Spiny mouse

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.1016/bs.ctdb.2021.12.017

Cite this

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title = "A remarkable rodent: Regeneration and reproduction in spiny mice (Acomys)",

abstract = "Although certain organisms are chosen and employed to better understand a specific problem in biology (so-called model organisms), sometimes an animal model reveals its' biomedical importance by happenstance. In many ways, the advent of spiny mice (Acomys) as an emerging model to study regeneration and menstruation stands as a case study in scientific pseudoserendipity (Diaz de Chumaceiro, 1995). As we recount in this chapter, the discovery of these phenotypes, while not entirely accidental, was nonetheless unexpected. In addition to recounting how we uncovered these unusual mammalian traits, we outline recent work by our groups and others that has begun to outline the cellular and genetic mechanisms underlying bonafide mammalian tissue regeneration and a human-like mode of reproduction in spiny mice.",

keywords = "Acomys, Ear pinna, Endometrium, Menstruation, Regeneration, Reproduction, Skin, Spiny mouse",

author = "Seifert, {Ashley W.} and Peter Temple-Smith",

note = "Funding Information: We would like to acknowledge those researchers that have pursued work with spiny mice in the past, often at great challenge. We would also like to thank the growing community of spiny mouse researchers that are committed to open science and that generously share information with each other about ongoing and future projects that facilitate our general understanding about these extraordinary rodents. Beyond those named in this chapter, Dr. Seifert would like to acknowledge the tireless work of several Kenyan field assistants, namely, James Ekiru Erkaran who was instrumental in trapping and site scouting in the early development of the regenerative biology work. Also, Stanley Marete in the Department of Veterinary Anatomy and Physiology at the University of Nairobi who has maintained ongoing colonies of A. kempi and A. percivali and the staff and scientists at Mpala Research Centre. Greg Schultz for his mentorship in all things wound healing. Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society. Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology. Funding Information: Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology. Funding Information: Beyond those named in this chapter, Dr. Seifert would like to acknowledge the tireless work of several Kenyan field assistants, namely, James Ekiru Erkaran who was instrumental in trapping and site scouting in the early development of the regenerative biology work. Also, Stanley Marete in the Department of Veterinary Anatomy and Physiology at the University of Nairobi who has maintained ongoing colonies of A. kempi and A. percivali and the staff and scientists at Mpala Research Centre. Greg Schultz for his mentorship in all things wound healing. Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = jan,

doi = "10.1016/bs.ctdb.2021.12.017",

language = "English",

isbn = "9780128201541",

series = "Current Topics in Developmental Biology",

pages = "659--707",

editor = "Bob Goldstein and Mansi Srivastava",

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Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society. Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology. Funding Information: Dr. Temple-Smith acknowledges David Walker, Stacey Ellery and the many researchers and students who, through their interest, enthusiasm and long hours in their laboratories, have provided the solid foundation on reproduction and development of spiny mice in the Monash colony that forms the basis of this chapter. Special thanks to Haley Dickinson for the productive collaborations on spiny mouse reproduction during her time at the Hudson Institute of Medical Research; Jared Mamrot for advancing our knowledge on embryo development in the spiny mouse and for permission to use (Fig. 8A and B) from his PhD thesis; Nadia Bellofiore for the fascinating discoveries, during her graduate research, of menstruation, premenstrual tension syndrome and absence of pseudo-pregnancy in the spiny mouse; Evgenia George for her detailed research findings on the spiny mouse ovarian reserve and who, with Nadia, demonstrated the spiny mouse transition-to-menopause; Jarrod McKenna for his detailed and important work on sperm cryopreservation, mating behavior and post-partum reproduction. I also acknowledge the generous support from the Bill and Melinda Gates Foundation (OPP1171535—The Spiny Mouse for Screening Contraceptive), the Pharmaceuticals Research and Development branch at Bayer AG Germany, the Monash University Education Program in Reproduction and Development and the Monash Department of Obstetrics and Gynecology. Funding Information: Beyond those named in this chapter, Dr. Seifert would like to acknowledge the tireless work of several Kenyan field assistants, namely, James Ekiru Erkaran who was instrumental in trapping and site scouting in the early development of the regenerative biology work. Also, Stanley Marete in the Department of Veterinary Anatomy and Physiology at the University of Nairobi who has maintained ongoing colonies of A. kempi and A. percivali and the staff and scientists at Mpala Research Centre. Greg Schultz for his mentorship in all things wound healing. Vanessa Ezenwa has been an amazing collaborator on the ecoimmunological aspects of spiny mice and continues to participate as part of our community. Thomas Gawriluk worked tirelessly in the field and back in the States to advance the spiny mouse model at the University of Kentucky. He also conducted the first reproductive biology studies in the Kentucky colony. Lastly, spiny mouse work in Dr. Seifert's lab has been generously supported by grants from the National Science Foundation (NSF) and the Office for International Science and Engineering (OISE) (IOS-1353713), the National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR070313), the National Institute of Dental and Craniofacial Research (NIDCR) (R21 DE028070) and a Grants-in-Aid of Research from the National Geographic Society. Publisher Copyright: © 2022 Elsevier Inc.

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A remarkable rodent: Regeneration and reproduction in spiny mice (Acomys)

Abstract

Publication series

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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