A remarkable rodent: Regeneration and reproduction in spiny mice (Acomys)

Ashley W. Seifert, Peter Temple-Smith

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Although certain organisms are chosen and employed to better understand a specific problem in biology (so-called model organisms), sometimes an animal model reveals its' biomedical importance by happenstance. In many ways, the advent of spiny mice (Acomys) as an emerging model to study regeneration and menstruation stands as a case study in scientific pseudoserendipity (Diaz de Chumaceiro, 1995). As we recount in this chapter, the discovery of these phenotypes, while not entirely accidental, was nonetheless unexpected. In addition to recounting how we uncovered these unusual mammalian traits, we outline recent work by our groups and others that has begun to outline the cellular and genetic mechanisms underlying bonafide mammalian tissue regeneration and a human-like mode of reproduction in spiny mice.

Original languageEnglish
Title of host publicationEmerging Model Systems in Developmental Biology
EditorsBob Goldstein, Mansi Srivastava
Pages659-707
Number of pages49
DOIs
StatePublished - Jan 2022

Publication series

NameCurrent Topics in Developmental Biology
Volume147
ISSN (Print)0070-2153

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

  • Acomys
  • Ear pinna
  • Endometrium
  • Menstruation
  • Regeneration
  • Reproduction
  • Skin
  • Spiny mouse

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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