TY - JOUR
T1 - A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury
AU - Longhi, Luca
AU - Saatman, Kathryn E.
AU - Raghupathi, Ramesh
AU - Laurer, Helmut L.
AU - Lenzlinger, Philipp M.
AU - Riess, Peter
AU - Neugebauer, Edmund
AU - Trojanowski, John Q.
AU - Lee, Virginia M.Y.
AU - Grady, M. Sean
AU - Graham, David I.
AU - McIntosh, Tracy K.
PY - 2001
Y1 - 2001
N2 - The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and pathologic aspects of human head injury, and the development of genetically engineered animals has offered the opportunity to investigate the specific molecular and cellular mechanisms associated with cell dysfunction and death after TBI, allowing for the evaluation of specific cause-effect relations and mechanistic hypotheses. This article represents a compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases.
AB - The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and pathologic aspects of human head injury, and the development of genetically engineered animals has offered the opportunity to investigate the specific molecular and cellular mechanisms associated with cell dysfunction and death after TBI, allowing for the evaluation of specific cause-effect relations and mechanistic hypotheses. This article represents a compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases.
KW - Cell death
KW - Head injury
KW - Inflammation
KW - Neurodegeneration
KW - Pathophysiology
KW - Secondary brain damage
KW - Transgenic mice
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U2 - 10.1097/00004647-200111000-00001
DO - 10.1097/00004647-200111000-00001
M3 - Review article
C2 - 11702040
AN - SCOPUS:0035203408
SN - 0271-678X
VL - 21
SP - 1241
EP - 1258
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 11
ER -
