A road less traveled by: Exploring a decade of Ellman chemistry

Anang A. Shelat, R. Kiplin Guy

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The Ellman group has been one of the most influential in the development and widespread adoption of combinatorial chemistry techniques for biomedical research. Their work has included substantial methodological development for library synthesis with a particular focus on new scaffolds rationally targeted to biomolecules of interest and biologically relevant natural products. Herein we analyze a representative set of libraries from this group with respect to their biological and biomedical relevance in comparison to existing drugs and probe compounds. This analysis reveals that the Ellman group has not only provided new methodologies to the community but also provided libraries with unique potential for further biological study.

Original languageEnglish
Pages (from-to)1088-1093
Number of pages6
JournalBioorganic and Medicinal Chemistry
Issue number3
StatePublished - Feb 1 2009

Bibliographical note

Funding Information:
This work was supported by the American Lebanese Syrian Associated Charities (ALSAC) and St. Jude Children’s Research Hospital.


  • Chemical space

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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