A selective solvent-free self-condensation of carbonyl compounds utilizing microwave irradiation

Lalit Kumar Sharma; Kyung Bo Kim; Gregory I. Elliott

doi:10.1039/c1gc15164a

A selective solvent-free self-condensation of carbonyl compounds utilizing microwave irradiation

Lalit Kumar Sharma, Kyung Bo Kim, Gregory I. Elliott

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

An environmentally benign microwave-assisted solvent-free self-condensation of carbonyl compounds was developed using catalytic amounts of triethylamine and lithium perchlorate. Changing the amount of lithium perchlorate helps in controlling the ratio of the single-condensation and double-condensation products. The effect of other additives and microwave activation was also investigated. The optimized conditions were then applied to various cyclic/acyclic ketones and aldehydes, with selectivity observed in many cases.

Original language	English
Pages (from-to)	1546-1549
Number of pages	4
Journal	Green Chemistry
Volume	13
Issue number	6
DOIs	https://doi.org/10.1039/c1gc15164a
State	Published - Jun 7 2011

ASJC Scopus subject areas

Environmental Chemistry
Pollution

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10.1039/c1gc15164a

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abstract = "An environmentally benign microwave-assisted solvent-free self-condensation of carbonyl compounds was developed using catalytic amounts of triethylamine and lithium perchlorate. Changing the amount of lithium perchlorate helps in controlling the ratio of the single-condensation and double-condensation products. The effect of other additives and microwave activation was also investigated. The optimized conditions were then applied to various cyclic/acyclic ketones and aldehydes, with selectivity observed in many cases.",

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AB - An environmentally benign microwave-assisted solvent-free self-condensation of carbonyl compounds was developed using catalytic amounts of triethylamine and lithium perchlorate. Changing the amount of lithium perchlorate helps in controlling the ratio of the single-condensation and double-condensation products. The effect of other additives and microwave activation was also investigated. The optimized conditions were then applied to various cyclic/acyclic ketones and aldehydes, with selectivity observed in many cases.

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A selective solvent-free self-condensation of carbonyl compounds utilizing microwave irradiation

Abstract

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