@article{ce75f187347047ffb1d5f175d2de7177,
title = "A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis",
abstract = "A set of 2-chloro-4-nitrophenyl glucosamino-/xylosaminosides were synthesized and assessed as potential substrates in the context of glycosyltransferase-catalyzed formation of the corresponding UDP/TDP-α-D-glucosamino-/xylosaminosugars and in single-vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki to be a proficient catalyst for U/TDP-aminosugar synthesis and utilization. 2-Chloro-4-nitrophenyl glucosamine-/xylosaminosides were synthesized and assessed as potential substrates for glycosyltransferase-catalyzed formation of the corresponding UDP/TDP-α-D-glucosamino-/xylosaminosugars and in single-vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki as a proficient catalyst for U/TDP-aminosugar synthesis.",
keywords = "carbohydrates, enzymes, glycobiology, glycorandomization, glycosides, glycosylation",
author = "Jianjun Zhang and Shanteri Singh and Hughes, \{Ryan R.\} and Maoquan Zhou and Manjula Sunkara and Morris, \{Andrew J.\} and Thorson, \{Jon S.\}",
year = "2014",
month = mar,
day = "21",
doi = "10.1002/cbic.201300779",
language = "English",
volume = "15",
pages = "647--651",
number = "5",
}