A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels

Dipti Biswal; Paritosh P. Wattamwar; Thomas D. Dziubla; J. Zach Hilt

doi:10.1016/j.polymer.2011.10.058

A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels

Dipti Biswal, Paritosh P. Wattamwar, Thomas D. Dziubla, J. Zach Hilt

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A novel one-step method for the preparation of poly(β-amino ester) hydrogels has been developed. The one-step method utilizes a Michael type addition reaction between a difunctional diacrylate and a tetrafunctional primary diamine to create a crosslinked biodegradable hydrogel. It was shown that the molar ratio of the reactive acrylate to amine controlled the extent of polymerization and crosslinking density of the hydrogel system, which enabled for the end properties of the network (e.g., swelling, degradation, and mechanical) to be tuned.

Original language	English
Pages (from-to)	5985-5992
Number of pages	8
Journal	Polymer
Volume	52
Issue number	26
DOIs	https://doi.org/10.1016/j.polymer.2011.10.058
State	Published - Dec 13 2011

Keywords

Hydrogel
Poly(β-amino ester)
Swelling

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1016/j.polymer.2011.10.058

Cite this

@article{b8b454468d5641bcaf2736362aa6567e,

title = "A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels",

abstract = "A novel one-step method for the preparation of poly(β-amino ester) hydrogels has been developed. The one-step method utilizes a Michael type addition reaction between a difunctional diacrylate and a tetrafunctional primary diamine to create a crosslinked biodegradable hydrogel. It was shown that the molar ratio of the reactive acrylate to amine controlled the extent of polymerization and crosslinking density of the hydrogel system, which enabled for the end properties of the network (e.g., swelling, degradation, and mechanical) to be tuned.",

keywords = "Hydrogel, Poly(β-amino ester), Swelling",

author = "Dipti Biswal and Wattamwar, {Paritosh P.} and Dziubla, {Thomas D.} and Hilt, {J. Zach}",

year = "2011",

month = dec,

day = "13",

doi = "10.1016/j.polymer.2011.10.058",

language = "English",

volume = "52",

pages = "5985--5992",

number = "26",

}

TY - JOUR

T1 - A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels

AU - Biswal, Dipti

AU - Wattamwar, Paritosh P.

AU - Dziubla, Thomas D.

AU - Hilt, J. Zach

PY - 2011/12/13

Y1 - 2011/12/13

N2 - A novel one-step method for the preparation of poly(β-amino ester) hydrogels has been developed. The one-step method utilizes a Michael type addition reaction between a difunctional diacrylate and a tetrafunctional primary diamine to create a crosslinked biodegradable hydrogel. It was shown that the molar ratio of the reactive acrylate to amine controlled the extent of polymerization and crosslinking density of the hydrogel system, which enabled for the end properties of the network (e.g., swelling, degradation, and mechanical) to be tuned.

AB - A novel one-step method for the preparation of poly(β-amino ester) hydrogels has been developed. The one-step method utilizes a Michael type addition reaction between a difunctional diacrylate and a tetrafunctional primary diamine to create a crosslinked biodegradable hydrogel. It was shown that the molar ratio of the reactive acrylate to amine controlled the extent of polymerization and crosslinking density of the hydrogel system, which enabled for the end properties of the network (e.g., swelling, degradation, and mechanical) to be tuned.

KW - Hydrogel

KW - Poly(β-amino ester)

KW - Swelling

UR - http://www.scopus.com/inward/record.url?scp=82755161808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82755161808&partnerID=8YFLogxK

U2 - 10.1016/j.polymer.2011.10.058

DO - 10.1016/j.polymer.2011.10.058

M3 - Article

AN - SCOPUS:82755161808

VL - 52

SP - 5985

EP - 5992

IS - 26

ER -

A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this