A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships

Bini Mathew, Timothy S. Snowden, Michele C. Connelly, R. Kiplin Guy, Robert C. Reynolds

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have a variety of potential indications that include management of pain and inflammation as well as chemoprevention and/or treatment of cancer. Furthermore, a specific form of ibuprofen, dexibuprofen or the S-(+) form, shows interesting neurological activities and has been proposed for the treatment of Alzheimer's disease. In a continuation of our work probing the anticancer activity of small sulindac libraries, we have prepared and screened a small diversity library of α-methyl substituted sulindac amides in the profen class. Several compounds of this series displayed promising activity compared with a lead sulindac analog.

Original languageEnglish
Pages (from-to)2136-2142
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume28
Issue number12
DOIs
StatePublished - Jul 1 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors

Keywords

  • Anticancer
  • Chemical biology
  • Chemoprevention
  • Profens
  • Sulindac

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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