A Solid-State Nanopore as Biosensor

Samuel Bearden, Guigen Zhang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Solid-state nanopores are important devices for future biosensing. They can be fabricated by using several different processing methods, such as selective etching, e-beam sculpting, and focused ion beam sculpting with a variety of materials. While the electrical and surface properties of the selected materials may affect the characteristics of nanopore behavior, different fabrication methods will also affect the shape of nanopores and sometimes even alter the electrical characteristics of the materials that make the nanopores. Because of such inherent complexity, analysis of the electrical and fluidic properties of a nanopore device requires the consideration of all relevant physics associated with the device. This may be accomplished by using either deterministic or probabilistic modeling techniques. Of particular importance to the modeling of the fluidics through a nanopore is the consideration of the electrical double layer. This chapter discusses the effects of various factors affecting the performance of a nanopore biosensor and presents a case study in which a nanopore consisting of a single-walled carbon nanotube is modeled.

Original languageEnglish
Title of host publicationComputational Bioengineering
Number of pages21
ISBN (Electronic)9781466517561
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© 2015 by Taylor and Francis Group, LLC.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Materials Science


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