A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes

E. Kurt Dolence; Maciej Adamczyk; David S. Watt; Graeme B. Russell; Dennis H.S. Horn

doi:10.1016/S0040-4039(00)98430-2

A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes

E. Kurt Dolence, Maciej Adamczyk, David S. Watt, Graeme B. Russell, Dennis H.S. Horn

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

The addition of lithium acetylides to (20R)-20-hydroxypregnane-22-carboxaldehydes in the absence and in the presence of BF₃ afforded predominantly 20R,22R- or 20R,22s-diols, respectively, characteristic of ecdysones.

Original language	English
Pages (from-to)	1189-1192
Number of pages	4
Journal	Tetrahedron Letters
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4039(00)98430-2
State	Published - 1985

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)98430-2

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@article{17f74b20d6f84671ad22b4ab12b5cf8c,

title = "A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes",

abstract = "The addition of lithium acetylides to (20R)-20-hydroxypregnane-22-carboxaldehydes in the absence and in the presence of BF3 afforded predominantly 20R,22R- or 20R,22s-diols, respectively, characteristic of ecdysones.",

author = "{Kurt Dolence}, E. and Maciej Adamczyk and Watt, {David S.} and Russell, {Graeme B.} and Horn, {Dennis H.S.}",

year = "1985",

doi = "10.1016/S0040-4039(00)98430-2",

language = "English",

volume = "26",

pages = "1189--1192",

number = "9",

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TY - JOUR

T1 - A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes

AU - Kurt Dolence, E.

AU - Adamczyk, Maciej

AU - Watt, David S.

AU - Russell, Graeme B.

AU - Horn, Dennis H.S.

PY - 1985

Y1 - 1985

N2 - The addition of lithium acetylides to (20R)-20-hydroxypregnane-22-carboxaldehydes in the absence and in the presence of BF3 afforded predominantly 20R,22R- or 20R,22s-diols, respectively, characteristic of ecdysones.

AB - The addition of lithium acetylides to (20R)-20-hydroxypregnane-22-carboxaldehydes in the absence and in the presence of BF3 afforded predominantly 20R,22R- or 20R,22s-diols, respectively, characteristic of ecdysones.

UR - http://www.scopus.com/inward/record.url?scp=0007168235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0007168235&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)98430-2

DO - 10.1016/S0040-4039(00)98430-2

M3 - Article

AN - SCOPUS:0007168235

SN - 0040-4039

VL - 26

SP - 1189

EP - 1192

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 9

ER -

A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes

Abstract

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