A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes

E. Kurt Dolence, Maciej Adamczyk, David S. Watt, Graeme B. Russell, Dennis H.S. Horn

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The addition of lithium acetylides to (20R)-20-hydroxypregnane-22-carboxaldehydes in the absence and in the presence of BF3 afforded predominantly 20R,22R- or 20R,22s-diols, respectively, characteristic of ecdysones.

Original languageEnglish
Pages (from-to)1189-1192
Number of pages4
JournalTetrahedron Letters
Issue number9
StatePublished - 1985

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'A stereoselective synthesis of 1,2-diols from α-hydroxyaldehydes'. Together they form a unique fingerprint.

Cite this