A sweet success for substrate engineering

Byron R. Griffith; Jon S. Thorson

doi:10.1038/nchembio1206-659

A sweet success for substrate engineering

Byron R. Griffith
, Jon S. Thorson

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Chemically synthesizing complex oligosaccharides remains a significant challenge. Through the addition of hydrophobic appendages to 'unnatural' substrates, some oligosaccharide-forming glycosyltransferases can direct the formation of distinct sugar linkages while maintaining stereoselectivity.

Original language	English
Pages (from-to)	659-660
Number of pages	2
Journal	Nature Chemical Biology
Volume	2
Issue number	12
DOIs	https://doi.org/10.1038/nchembio1206-659
State	Published - Dec 2006

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "A sweet success for substrate engineering",

abstract = "Chemically synthesizing complex oligosaccharides remains a significant challenge. Through the addition of hydrophobic appendages to 'unnatural' substrates, some oligosaccharide-forming glycosyltransferases can direct the formation of distinct sugar linkages while maintaining stereoselectivity.",

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AU - Griffith, Byron R.

AU - Thorson, Jon S.

PY - 2006/12

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AB - Chemically synthesizing complex oligosaccharides remains a significant challenge. Through the addition of hydrophobic appendages to 'unnatural' substrates, some oligosaccharide-forming glycosyltransferases can direct the formation of distinct sugar linkages while maintaining stereoselectivity.

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DO - 10.1038/nchembio1206-659

M3 - Short survey

C2 - 17108980

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VL - 2

SP - 659

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JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 12

ER -

A sweet success for substrate engineering

Abstract

ASJC Scopus subject areas

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