Abstract
The transformation of cyclic anhydrides to their corresponding imides involves a mild three-step sequence: (1) reaction with a primary amine, (2) conversion of the intermediate monoamide to an N-hydroxysuccinimidyl ester using N,N′-disuccinimidyl oxalate (DSO), and (3) cyclization by heating the NHS ester in trichloroethylene in the presence of 4-(dimethylamino)pyridine.
Original language | English |
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Pages (from-to) | 919-922 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 27 |
Issue number | 8 |
DOIs | |
State | Published - 1986 |
Bibliographical note
Funding Information:Acknowledgement. We thank the National Institutes of Health (HD 20780) for their generous financial support and the Midwest Center for Mass Spectrometry for exact mass determinations.
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry