The transformation of cyclic anhydrides to their corresponding imides involves a mild three-step sequence: (1) reaction with a primary amine, (2) conversion of the intermediate monoamide to an N-hydroxysuccinimidyl ester using N,N′-disuccinimidyl oxalate (DSO), and (3) cyclization by heating the NHS ester in trichloroethylene in the presence of 4-(dimethylamino)pyridine.
|Number of pages||4|
|State||Published - 1986|
Bibliographical noteFunding Information:
Acknowledgement. We thank the National Institutes of Health (HD 20780) for their generous financial support and the Midwest Center for Mass Spectrometry for exact mass determinations.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry