TY - JOUR
T1 - A systematic study of the relationship between molecular and crystal structure among 3,5-diazabicyclo[2.2.2]octane-2,6-diones
AU - Brewer, Jason T.
AU - Parkin, Sean
AU - Grossman, Robert B.
PY - 2004/5
Y1 - 2004/5
N2 - A simple, convergent synthesis of 3,5-diazabicyclo[2.2.2]octane-2,6-diones (bicyclic N,N′-diacylaminals) has been developed, providing access to a large series of compounds differing only in their substituents at the bridgehead positions. These compounds crystallize in several different forms, but always in such a way that each molecule forms four hydrogen bonds. The sheer number of bicyclic amidals that can be synthesized and crystallized provides an opportunity to elucidate crystal-engineering structure-structure relationship (SSR) principles.
AB - A simple, convergent synthesis of 3,5-diazabicyclo[2.2.2]octane-2,6-diones (bicyclic N,N′-diacylaminals) has been developed, providing access to a large series of compounds differing only in their substituents at the bridgehead positions. These compounds crystallize in several different forms, but always in such a way that each molecule forms four hydrogen bonds. The sheer number of bicyclic amidals that can be synthesized and crystallized provides an opportunity to elucidate crystal-engineering structure-structure relationship (SSR) principles.
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U2 - 10.1021/cg0341609
DO - 10.1021/cg0341609
M3 - Article
AN - SCOPUS:2542522195
SN - 1528-7483
VL - 4
SP - 591
EP - 594
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 3
ER -