A text messaging intervention to promote medication adherence for patients with coronary heart disease: A randomized controlled trial

Linda G. Park, Jill Howie-Esquivel, Misook L. Chung, Kathleen Dracup

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


Objective: Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM. Methods: A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA. Results: Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken ( p= 0.02), percentage number of doses taken ( p= 0.01), and percentage of prescribed doses taken on schedule ( p= 0.01). TM response rates were higher for antiplatelets than statins ( p= 0.005). Self-reported adherence revealed no significant differences among groups. Conclusion: TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses. Practice implications: Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalPatient Education and Counseling
Issue number2
StatePublished - Feb 2014

Bibliographical note

Funding Information:
Funding for research materials was provided by a grant from the Graduate Division of University of California, San Francisco and a scholarship from the UCSF/Hartford Center of Geriatric Nursing Excellence. CareSpeak Communications provided the use of the mobile Health manager platform, which is designed to improve medical therapy adherence using two-way text messaging.


  • Antiplatelets
  • Coronary heart disease
  • Medication adherence
  • Mobile phone
  • Statins
  • Text messaging

ASJC Scopus subject areas

  • Medicine (all)


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