A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Cassandra D. Gipson, Joshua S. Beckmann, Zack W. Adams, Julie A. Marusich, Travis O. Nesland, Justin R. Yates, Thomas H. Kelly, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalDrug and Alcohol Dependence
Issue number1-2
StatePublished - Apr 1 2012

Bibliographical note

Funding Information:
This work was supported by NIH Grants F31 DA028018 , P50 DA05312 , and T32 DA007304 . Additionally, this work was supported, in part, by the University of Kentucky Center on Drug and Alcohol Research, the American Psychological Association Science Directorate Dissertation Research Award, the American Psychological Association Division 28 Outstanding Dissertation Award, and the Dissertation Fellowship from the Graduate School at the University of Kentucky.


  • Amphetamine
  • Impulsivity
  • Negative urgency
  • Self-administration
  • Substance abuse
  • Translational research

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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