A very stable cyclic DNA miniduplex with just two base pairs

Afaf H. El-Sagheer, Ravindra Kumar, Stuart Findlow, Joern M. Werner, Andrew N. Lane, Tom Brown

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
Issue number1
StatePublished - Jan 4 2008


  • Cyclic
  • DNA
  • DNA recognition
  • DNA structure
  • Miniduplex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry


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