A Wearable Fiberless Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Mice

Chong Huang, Yutong Gu, Jing Chen, Ahmed A. Bahrani, Elie G.Abu Jawdeh, Henrietta S. Bada, Kathryn Saatman, Guoqiang Yu, Lei Chen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Continuous and longitudinal monitoring of cerebral blood flow (CBF) in animal models provides information for studying the mechanisms and interventions of various cerebral diseases. Since anesthesia may affect brain hemodynamics, researchers have been seeking wearable devices for use in conscious animals. We present a wearable diffuse speckle contrast flowmeter (DSCF) probe for monitoring CBF variations in mice. The DSCF probe consists of a small low-power near-infrared laser diode as a point source and an ultrasmall low-power CMOS camera as a two-dimensional detector array, which can be affixed on a mouse head. The movement of red blood cells in brain cortex (i.e., CBF) produces spatial fluctuations of laser speckles, which are captured by the camera. The DSCF system was calibrated using tissue phantoms and validated in a human forearm and mouse brains for continuous monitoring of blood flow increases and decreases against the established technologies. Significant correlations were observed among these measurements (R2 ≥ 0.80p <10-5). This small fiberless probe has the potential to be worn by a freely moving conscious mouse. Moreover, the flexible source-detector configuration allows for varied probing depths up to {∼8 mm, which is sufficient for transcranially detecting CBF in the cortices of rodents and newborn infants.

Original languageEnglish
Article number6900108
JournalIEEE Journal of Selected Topics in Quantum Electronics
Issue number1
StatePublished - Jan 1 2019

Bibliographical note

Funding Information:
Manuscript received April 3, 2018; revised May 23, 2018 and June 15, 2018; accepted June 18, 2018. Date of publication July 9, 2018; date of current version January 17, 2019. This work was supported in part by the National Institutes of Health (R21-HD091118, R21-AR062356, R21-AG046762, and COBRE 1P20GM121327); in part by the American Heart Association (16GRNT30820006 and 14SDG20480186); and in part by the National Science Foundation under Grant 1539068. (Corresponding authors: Guoqiang Yu and Lei Chen.) C. Huang, J. Chen, A. A. Bahrani, and G. Yu are with the Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506 USA (e-mail:, chong.huang@uky.edu; jingchen.sophia@gmail.com; ahmed. bahrani@uky.edu; guoqiang.yu@uky.edu).

Publisher Copyright:
© 1995-2012 IEEE.


  • Optical spectroscopy
  • blood flow measurement
  • brain
  • implantable biomedical devices

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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