Abstract
Continuous and longitudinal monitoring of cerebral blood flow (CBF) in animal models provides information for studying the mechanisms and interventions of various cerebral diseases. Since anesthesia may affect brain hemodynamics, researchers have been seeking wearable devices for use in conscious animals. We present a wearable diffuse speckle contrast flowmeter (DSCF) probe for monitoring CBF variations in mice. The DSCF probe consists of a small low-power near-infrared laser diode as a point source and an ultrasmall low-power CMOS camera as a two-dimensional detector array, which can be affixed on a mouse head. The movement of red blood cells in brain cortex (i.e., CBF) produces spatial fluctuations of laser speckles, which are captured by the camera. The DSCF system was calibrated using tissue phantoms and validated in a human forearm and mouse brains for continuous monitoring of blood flow increases and decreases against the established technologies. Significant correlations were observed among these measurements (R2 ≥ 0.80p <10-5). This small fiberless probe has the potential to be worn by a freely moving conscious mouse. Moreover, the flexible source-detector configuration allows for varied probing depths up to {∼8 mm, which is sufficient for transcranially detecting CBF in the cortices of rodents and newborn infants.
Original language | English |
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Article number | 6900108 |
Journal | IEEE Journal of Selected Topics in Quantum Electronics |
Volume | 25 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2019 |
Bibliographical note
Publisher Copyright:© 1995-2012 IEEE.
Keywords
- Optical spectroscopy
- blood flow measurement
- brain
- implantable biomedical devices
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering