TY - JOUR
T1 - AAA+ proteins
T2 - Have engine, will work
AU - Hanson, Phyllis I.
AU - Whiteheart, Sidney W.
PY - 2005/7
Y1 - 2005/7
N2 - AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
AB - AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=21744446127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21744446127&partnerID=8YFLogxK
U2 - 10.1038/nrm1684
DO - 10.1038/nrm1684
M3 - Review article
C2 - 16072036
AN - SCOPUS:21744446127
SN - 1471-0072
VL - 6
SP - 519
EP - 529
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 7
ER -