AAA+ proteins: Have engine, will work

Phyllis I. Hanson, Sidney W. Whiteheart

Research output: Contribution to journalReview articlepeer-review

935 Scopus citations

Abstract

AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.

Original languageEnglish
Pages (from-to)519-529
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume6
Issue number7
DOIs
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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