Absence of detectable pharmacological effects after oral administration of isoxsuprine

J. D. Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, T. Tobin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalEquine Veterinary Journal
Issue number4
StatePublished - 1998


  • Behaviour chamber
  • Cutaneous blood flow
  • Heart rate
  • Horse
  • Isoxsuprine
  • Muscle tone
  • Pharmacological effect
  • Sweat production
  • Temperature

ASJC Scopus subject areas

  • Equine


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