Abstract
A family of glycoproteins sharing an epitope with myelin associated glycoprotein as recognized by the monoclonal antibody Leu 7 (HNK-1) has been found to be present on neurons grown in culture from embryonic chicks and rats. Immunofluorescent staining demonstrates that, in vitro, 100% of the neurons from dorsal root ganglia and spinal cord from 7-8 day chick embryos react with Leu 7. Analysis of in vitro regenerative neurite formation by neurons on substrates enriched with Leu 7 showed accelerated regenerative process formation under limiting conditions. These results indicate that the Leu 7 epitope on neurons is appropriate for substrate adhesion and promotes rapid process extension.
| Original language | English |
|---|---|
| Pages (from-to) | 95-100 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 56 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 14 1985 |
Funding
This work was supported by the Multiple Sclerosis Society of Canada (J.R.) and the Medical Research Council of Canada (R.J.R.). R.M. is a fellow of the M.S. Society of Canada.
| Funders |
|---|
| Multiple Sclerosis Society of Canada |
| Medical Research Council Canada |
Keywords
- HNK-1
- Leu 7
- MAG
- monoclonal antibody
- myelin associated glycoprotein
- neurite formation
- neurons
ASJC Scopus subject areas
- General Neuroscience
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