Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels

Francisco J. Diaz; Alexander Meary; Maria J. Arranz; Gualberto Ruaño; Andreas Windemuth; Jose de Leon

doi:10.1016/j.schres.2009.09.038

Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels

Francisco J. Diaz, Alexander Meary, Maria J. Arranz, Gualberto Ruaño, Andreas Windemuth, Jose de Leon

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs were not significant.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Schizophrenia Research
Volume	115
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2009.09.038
State	Published - Dec 2009

Bibliographical note

Funding Information:
No pharmaceutical organizations had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Genotyping and statistical analyses were conducted without additional external support. Genotyping of the original SNPs described in prior article were conducted at Genomas, Hartford, CT by Mohan Kocherla.

Keywords

Acetyl-coenzyme A carboxylase alpha
Acetyl-coenzyme A carboxylase beta
Antipsychotics
Chlorpromazine
Cholesterol
Hypercholesterolemia
Hypertriglyceridemia
Lipids
Metabolic syndrome
Mirtazapine
Neuropeptide Y
Olanzapine
Quetiapine
Triglycerides

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2009.09.038

Cite this

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title = "Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels",

abstract = "Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs were not significant.",

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author = "Diaz, {Francisco J.} and Alexander Meary and Arranz, {Maria J.} and Gualberto Rua{\~n}o and Andreas Windemuth and {de Leon}, Jose",

note = "Funding Information: No pharmaceutical organizations had any role in the writing of this paper for publication. The original pharmacogenetic study at the University of Kentucky Mental Health Research Center was supported by several sources: a researcher-initiated grant from Roche Molecular Systems, Inc., a NARSAD Independent Investigator Award to Jose de Leon, M.D, and internal resources. Genotyping and statistical analyses were conducted without additional external support. Genotyping of the original SNPs described in prior article were conducted at Genomas, Hartford, CT by Mohan Kocherla. ",

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AU - Ruaño, Gualberto

AU - Windemuth, Andreas

AU - de Leon, Jose

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N2 - Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs were not significant.

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KW - Triglycerides

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Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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