TY - JOUR
T1 - Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB
AU - Nelson, Peter T.
AU - Kryscio, Richard J.
AU - Abner, Erin L.
AU - Schmitt, Frederick A.
AU - Jicha, Gregory A.
AU - Mendiondo, Marta S.
AU - Cooper, Greg
AU - Smith, Charles B.
AU - Markesbery, William R.
PY - 2009
Y1 - 2009
N2 - Dementia can be caused by different diseases including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n = 156). Patients with important concomitant pathology (n = 5) or patients that were profoundly demented at recruitment (intake MMSE < 20; n = 86) were excluded to strengthen our ability to test the association of specific clinical and pathological indices. Patients with pathologically-diagnosed AD + DLB (n = 25) lost cognitive capacity faster than patients with AD alone (n = 40). In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline.
AB - Dementia can be caused by different diseases including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n = 156). Patients with important concomitant pathology (n = 5) or patients that were profoundly demented at recruitment (intake MMSE < 20; n = 86) were excluded to strengthen our ability to test the association of specific clinical and pathological indices. Patients with pathologically-diagnosed AD + DLB (n = 25) lost cognitive capacity faster than patients with AD alone (n = 40). In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline.
KW - Acetycholinesterase
KW - Acetylcholinesterase inhibitors
KW - Alzheimer's disease
KW - Cholinesterase
KW - Dementia with Lewy bodies
KW - Neuropathology
UR - http://www.scopus.com/inward/record.url?scp=58849099937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58849099937&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-0926
DO - 10.3233/JAD-2009-0926
M3 - Article
C2 - 19158418
AN - SCOPUS:58849099937
SN - 1387-2877
VL - 16
SP - 29
EP - 34
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -