Acid-Sensing ion channels and pain

Qihai Gu; Lu Yuan Lee

doi:10.3390/ph3051411

Acid-Sensing ion channels and pain

Qihai Gu, Lu Yuan Lee

Research output: Contribution to journal › Review article › peer-review

28 Citations (SciVal)

Abstract

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.

Original language	English
Pages (from-to)	1411-1425
Number of pages	15
Journal	Pharmaceuticals
Volume	3
Issue number	5
DOIs	https://doi.org/10.3390/ph3051411
State	Published - 2010

Keywords

Acid sensing ion channel
Acidosis
Inflammation
Nociceptor
Pain

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science

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10.3390/ph3051411

Cite this

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abstract = "Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.",

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AB - Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.

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KW - Nociceptor

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Acid-Sensing ion channels and pain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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