Acid-Sensing ion channels and pain

Qihai Gu, Lu Yuan Lee

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.

Original languageEnglish
Pages (from-to)1411-1425
Number of pages15
JournalPharmaceuticals
Volume3
Issue number5
DOIs
StatePublished - 2010

Keywords

  • Acid sensing ion channel
  • Acidosis
  • Inflammation
  • Nociceptor
  • Pain

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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