Abstract
The study aimed to examine the association between objective estimates of sleep duration and quality and aortic stiffness while accounting for the potential confounding effect of sleep-disordered breathing. Participants were part of the Multi-Ethnic Study of Atherosclerosis Sleep study. Sleep duration and quality were assessed by 7-day wrist actigraphy, sleep-disordered breathing by home polysomnography, and aortic stiffness by magnetic resonance imaging–based aortic pulse wave velocity (aPWV), ascending and descending aorta distensibility. Aortic stiffness of participants with “normal” sleep duration (6-8 hours) were compared with those of “short” (<6 hours) and “long” sleep duration (>8 hours) adjusting for common cardiovascular risk factors and apnea-hypopnea index. The sample consisted of 908 participants (mean age 68.4 ± 9.1 years, 55.3% female). There was a significant linear trend of increased aPWV across short (n = 252), normal (n = 552), and long sleep durations (n = 104) (P for trend = .008). Multivariable analysis showed that people with short sleep duration had 0.94 m/s lower aPWV (95% CI: −1.54, −0.35), compared with those with normal sleep duration. In this ethnically diverse community cohort, habitual short sleep duration as estimated by actigraphy was associated with lower aortic stiffness.
| Original language | English |
|---|---|
| Pages (from-to) | 841-849 |
| Number of pages | 9 |
| Journal | Journal of the American Society of Hypertension |
| Volume | 12 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2018 |
Bibliographical note
Funding Information:The authors thank all the investigators, the staff, and the research participants of the MESA for their valuable contributions. Sources of Support: MESA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001881, and DK06349. Funding support for the Sleep Polysomnography dataset was provided by grant HL56984. SR was supported by R35 HL135818. full list of participating MESA investigators and institutions can be found athttp://www.mesa-nhlbi.org. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. Dr. Susan Redline is partly funded through the National Heart, Lung, and Blood Institute (1R35 HL135818-01).
Funding Information:
Sources of Support: MESA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001881, and DK06349. Funding support for the Sleep Polysomnography dataset was provided by grant HL56984. SR was supported by R35 HL135818. full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. Dr. Susan Redline is partly funded through the National Heart, Lung, and Blood Institute (1R35 HL135818-01).
Publisher Copyright:
© 2018 American Heart Association
Keywords
- Arterial stiffness
- pulse wave velocity
- sleep duration
- sleep quality
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine