Actions of phencyclidine on the action potential and membrane currents of single guinea-pig myocytes

R. W. Hadley, J. R. Hume

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The direct actions of phencyclidine (PCP) on mammalian sarcolemma were examined by determination of the drug's effects on the action potentials of isolated guinea-pig ventricular cells, and on the underlying ionic currents. PCP (10-6 to 10-4 M) did not alter the resting membrane potential but produced a dose-dependent prolongation of the duration of the action potential, and a reduction of the rate of depolarization of phase 0 (V(max)) of the action potential. Voltage clamp experiments revealed that PCP blocks both myocardial Ca++ channels and myocardial time-dependent K+ channels. The K+ channel blockade was shown to exhibit an apparent voltage-dependence. The effects of PCP on these ionic channels could explain previous reports of it prolonging myocardial action potentials and conflicting reports of positive and negative inotropism.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume237
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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