Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

W. D. Ehmann, X. X. Ding, S. S. Khare, M. A. Lovell, B. F. Ni, L. Tandon, D. E. Vance, D. E. Wenstrup

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

It has been suggested that several age-related neurological diseases such as Alzheimer's disease and amyotrophic lateral sclerosis may be related to environmental toxins. Bulk sample multielement analyses by INAA alone are not adequate to define the role of trace elements in these diseases. A multitechnique approach has been developed that incorporates 14 MeV, instrumental reactor, radiochemical, and pre-irradiation chemical neutron activation analysis, together with laser microprobe mass spectrometry. The analytical scheme is able to provide bulk or protein normalized elemental concentrations, as well as microstructural, cellular, and subcellular localization information.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalJournal of Radioanalytical and Nuclear Chemistry Articles
Volume168
Issue number1
DOIs
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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