Activation of ERα is necessary for estradiol's anorexigenic effect in female rats

Jessica Santollo, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Lisa A. Eckel

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.

Original languageEnglish
Pages (from-to)872-877
Number of pages6
JournalHormones and Behavior
Issue number5
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This work was supported by grants from the NIH : NS-062667 (JS), CA-018119 (BSK), DK-015556 (JAK), and DK-073936 (LAE).


  • Estradiol
  • Estrogen receptor
  • Estrous cycle
  • Food intake
  • MPrP

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience


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