Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Lalit Kumar Sharma; Na Ra Lee; Eun Ryoung Jang; Beilei Lei; Chang Guo Zhan; Wooin Lee; Kyung Bo Kim

doi:10.1002/cbic.201200307

Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Lalit Kumar Sharma, Na Ra Lee, Eun Ryoung Jang, Beilei Lei, Chang Guo Zhan, Wooin Lee, Kyung Bo Kim

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

Original language	English
Pages (from-to)	1899-1903
Number of pages	5
Journal	ChemBioChem
Volume	13
Issue number	13
DOIs	https://doi.org/10.1002/cbic.201200307
State	Published - Sep 3 2012

Keywords

Activity-based probes
Immunoproteasome
Near-infrared fluorescent probes
Proteomics

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cbic.201200307

Cite this

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abstract = "Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.",

keywords = "Activity-based probes, Immunoproteasome, Near-infrared fluorescent probes, Proteomics",

author = "Sharma, {Lalit Kumar} and Lee, {Na Ra} and Jang, {Eun Ryoung} and Beilei Lei and Zhan, {Chang Guo} and Wooin Lee and Kim, {Kyung Bo}",

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T2 - A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

AU - Sharma, Lalit Kumar

AU - Lee, Na Ra

AU - Jang, Eun Ryoung

AU - Lei, Beilei

AU - Zhan, Chang Guo

AU - Lee, Wooin

AU - Kim, Kyung Bo

PY - 2012/9/3

Y1 - 2012/9/3

N2 - Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

AB - Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

KW - Activity-based probes

KW - Immunoproteasome

KW - Near-infrared fluorescent probes

KW - Proteomics

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Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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