Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

Lalit Kumar Sharma, Na Ra Lee, Eun Ryoung Jang, Beilei Lei, Chang Guo Zhan, Wooin Lee, Kyung Bo Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

Original languageEnglish
Pages (from-to)1899-1903
Number of pages5
JournalChemBioChem
Volume13
Issue number13
DOIs
StatePublished - Sep 3 2012

Funding

FundersFunder number
National Childhood Cancer Registry – National Cancer InstituteR01CA128903

    Keywords

    • Activity-based probes
    • Immunoproteasome
    • Near-infrared fluorescent probes
    • Proteomics

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells'. Together they form a unique fingerprint.

    Cite this