Activity-dependent mapping in the retinotectal projection

Elizabeth A. Debski, Hollis T. Cline

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations


It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 1 2002

ASJC Scopus subject areas

  • General Neuroscience


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