TY - JOUR
T1 - Activity-dependent mapping in the retinotectal projection
AU - Debski, Elizabeth A.
AU - Cline, Hollis T.
PY - 2002/2/1
Y1 - 2002/2/1
N2 - It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.
AB - It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.
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U2 - 10.1016/S0959-4388(02)00295-7
DO - 10.1016/S0959-4388(02)00295-7
M3 - Review article
C2 - 11861170
AN - SCOPUS:0036471970
SN - 0959-4388
VL - 12
SP - 93
EP - 99
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -