Abstract
Previous research has shown that reductions in body weight prior to induction of acute inflammation can attenuate inflammation-induced anorexia in male rats. In the current study, potential mechanisms responsible for this observation were examined. Specifically, the effect of a 12% prior reduction in body weight on serum leptin, insulin, and corticosterone; levels of interleukin-1 (IL-1), interleukin-6 (IL-6) in the serum, liver, and spleen; neuropeptide Y (NPY) and POMC mRNA levels in the arcuate nucleus (ARC) of the hypothalamus were examined 8 h after induction of acute inflammation. Rats with prior weight reduction had significantly lower serum leptin levels and gene expression of POMC in the ARC than normal-weight rats. In contrast, prior weight reduction altered neither NPY mRNA in the ARC, nor IL-1α, IL-1β, and IL-6 levels in the serum, liver, and spleen. These results suggest that the attenuation of inflammation-induced anorexia by prior weight reduction is not due to altered cytokine activity, but rather to changes in energy regulatory systems that moderate the anorexic actions of IL-1β and IL-6. One potential change may be reduced activity of the CNS melanocortin system induced by decreased circulating leptin.
Original language | English |
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Pages (from-to) | 517-523 |
Number of pages | 7 |
Journal | Physiology and Behavior |
Volume | 73 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Bibliographical note
Funding Information:TAL was supported by a grant from NIH (NR04783). RJS was supported by grants from NIH (DK54080 and DK54890), as well as funds from the Procter & Gamble.
Funding
TAL was supported by a grant from NIH (NR04783). RJS was supported by grants from NIH (DK54080 and DK54890), as well as funds from the Procter & Gamble.
Funders | Funder number |
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National Institutes of Health (NIH) | NR04783, DK54890 |
National Institute of Diabetes and Digestive and Kidney Diseases | R01DK054080 |
Proctor and Gamble |
Keywords
- Body weight loss
- IL-1β
- IL-6
- Inflammation-induced anorexia
- Leptin
- POMC
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience