Previous research has shown that reductions in body weight prior to induction of acute inflammation can attenuate inflammation-induced anorexia in male rats. In the current study, potential mechanisms responsible for this observation were examined. Specifically, the effect of a 12% prior reduction in body weight on serum leptin, insulin, and corticosterone; levels of interleukin-1 (IL-1), interleukin-6 (IL-6) in the serum, liver, and spleen; neuropeptide Y (NPY) and POMC mRNA levels in the arcuate nucleus (ARC) of the hypothalamus were examined 8 h after induction of acute inflammation. Rats with prior weight reduction had significantly lower serum leptin levels and gene expression of POMC in the ARC than normal-weight rats. In contrast, prior weight reduction altered neither NPY mRNA in the ARC, nor IL-1α, IL-1β, and IL-6 levels in the serum, liver, and spleen. These results suggest that the attenuation of inflammation-induced anorexia by prior weight reduction is not due to altered cytokine activity, but rather to changes in energy regulatory systems that moderate the anorexic actions of IL-1β and IL-6. One potential change may be reduced activity of the CNS melanocortin system induced by decreased circulating leptin.
|Number of pages
|Physiology and Behavior
|Published - 2001
Bibliographical noteFunding Information:
TAL was supported by a grant from NIH (NR04783). RJS was supported by grants from NIH (DK54080 and DK54890), as well as funds from the Procter & Gamble.
- Body weight loss
- Inflammation-induced anorexia
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience