Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans

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19 Scopus citations


Recent clinical research indicates that d-amphetamine is effective in treating cocaine and methamphetamine dependence. There is concern, however, with the use of d-amphetamine as a pharmacotherapy because acute administration of d-amphetamine decreases inhibition in cocaine-using individuals and may increase drug-taking behavior. The purpose of the present experiment was to determine whether acute d-amphetamine pretreatment would alter the reinforcing, subject-rated, and cardiovascular effects of d-amphetamine. To this end, 7 human volunteers first sampled doses of oral d-amphetamine (0, 8, and 16 mg). These doses engender moderate drug taking and were selected to avoid a ceiling or floor effect. Volunteers were then allowed to self-administer these sampled doses using a modified progressive-ratio procedure in two sessions in which they received pretreatment with either 0 or 15 mg oral d-amphetamine 2 h prior to completing the modified progressive-ratio procedure. d-Amphetamine produced prototypical stimulant-like effects (e.g., increased ratings of stimulated, elevated blood pressure) and maintained responding on the modified progressive-ratio schedule. Pretreatment with 15 mg oral d-amphetamine also produced prototypical stimulant-like effects, but failed to alter break points for d-amphetamine on the modified progressive-ratio procedure relative to placebo pretreatment. These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration.

Original languageEnglish
Pages (from-to)20-29
Number of pages10
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - May 2007

Bibliographical note

Funding Information:
This research was supported by Grant DA 021155 from the National Institute on Drug Abuse (C.R.R.). The authors wish to thank Frances Wagner, RN, John Blackburn, Michelle Gray, Neena Khanna, Derek Roe and Kristi Yingling for their expert medical and technical assistance.


  • Agonist pharmacotherapy
  • Human
  • Pretreatment
  • Progressive-ratio
  • Reinforcement
  • Subject-rated effects
  • d-Amphetamine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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