Acute drug-use-related native tricuspid valve infective endocarditis: a non-surgical disease

Sami El-Dalati; Talal Alnabelsi; John Gurley; Kelli Cremeans; Hassan Reda; Tessa London-Bounds; Erinn Ogburn; Michael Sekela

doi:10.1177/20499361241267124

Acute drug-use-related native tricuspid valve infective endocarditis: a non-surgical disease

Sami El-Dalati, Talal Alnabelsi, John Gurley, Kelli Cremeans, Hassan Reda, Tessa London-Bounds, Erinn Ogburn, Michael Sekela

Research output: Contribution to journal › Review article › peer-review

Abstract

As a result of the ongoing opioid epidemic, physicians have encountered increasing rates of drug-use-related native tricuspid valve infective endocarditis (DU-TVIE), a complex multi-faceted disease that is best managed by interdisciplinary teams. Despite the large number of patients with DU-TVIE, there is little data to support the optimal treatment strategy with respect to medical and surgical therapy. The recent introduction of percutaneous mechanical aspiration of tricuspid valve vegetations has added another treatment modality that is also of uncertain benefit. Here we review the literature on the management of DU-TVIE and highlight the multi-step treatment approach developed by the multidisciplinary endocarditis team at the University of Kentucky.

Original language	English
Journal	Therapeutic Advances in Infectious Disease
Volume	11
DOIs	https://doi.org/10.1177/20499361241267124
State	Published - Jan 1 2024

Bibliographical note

Publisher Copyright:
© The Author(s), 2024.

Keywords

endocarditis
multidisciplinary teams
substance use disorder
tricuspid valve disease

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/20499361241267124

Cite this

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title = "Acute drug-use-related native tricuspid valve infective endocarditis: a non-surgical disease",

abstract = "As a result of the ongoing opioid epidemic, physicians have encountered increasing rates of drug-use-related native tricuspid valve infective endocarditis (DU-TVIE), a complex multi-faceted disease that is best managed by interdisciplinary teams. Despite the large number of patients with DU-TVIE, there is little data to support the optimal treatment strategy with respect to medical and surgical therapy. The recent introduction of percutaneous mechanical aspiration of tricuspid valve vegetations has added another treatment modality that is also of uncertain benefit. Here we review the literature on the management of DU-TVIE and highlight the multi-step treatment approach developed by the multidisciplinary endocarditis team at the University of Kentucky.",

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T2 - a non-surgical disease

AU - El-Dalati, Sami

AU - Alnabelsi, Talal

AU - Gurley, John

AU - Cremeans, Kelli

AU - Reda, Hassan

AU - London-Bounds, Tessa

AU - Ogburn, Erinn

AU - Sekela, Michael

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Y1 - 2024/1/1

N2 - As a result of the ongoing opioid epidemic, physicians have encountered increasing rates of drug-use-related native tricuspid valve infective endocarditis (DU-TVIE), a complex multi-faceted disease that is best managed by interdisciplinary teams. Despite the large number of patients with DU-TVIE, there is little data to support the optimal treatment strategy with respect to medical and surgical therapy. The recent introduction of percutaneous mechanical aspiration of tricuspid valve vegetations has added another treatment modality that is also of uncertain benefit. Here we review the literature on the management of DU-TVIE and highlight the multi-step treatment approach developed by the multidisciplinary endocarditis team at the University of Kentucky.

AB - As a result of the ongoing opioid epidemic, physicians have encountered increasing rates of drug-use-related native tricuspid valve infective endocarditis (DU-TVIE), a complex multi-faceted disease that is best managed by interdisciplinary teams. Despite the large number of patients with DU-TVIE, there is little data to support the optimal treatment strategy with respect to medical and surgical therapy. The recent introduction of percutaneous mechanical aspiration of tricuspid valve vegetations has added another treatment modality that is also of uncertain benefit. Here we review the literature on the management of DU-TVIE and highlight the multi-step treatment approach developed by the multidisciplinary endocarditis team at the University of Kentucky.

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KW - multidisciplinary teams

KW - substance use disorder

KW - tricuspid valve disease

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Acute drug-use-related native tricuspid valve infective endocarditis: a non-surgical disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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