Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

Edward D. Hall, J. Mark Braughler

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalExperimental Neurology
Volume73
Issue number1
DOIs
StatePublished - Jul 1981

Bibliographical note

Funding Information:
Abbreviations: MP-methylprednisolone sodium succinate, MDA-malonyldialdehyde. ’ The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman and a gift of methylprednisolone sodium succinate (Solu-Medrol) from the Upjohn Co., Kalamazoo, Michigan. This research was supported by a grant to E.D.H. from the Amyotrophic Lateral Sclerosis Society of America. Address all correspondence to E.D.H.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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