The effects of a large intravenous dose of the glucocorticoid methylprednisolone on lipid peroxide formation in cat lumbar spinal cord homogenate was examined using the thiobarbituric acid test for malonyldialdehyde production. One hour after the injection of a 30-mg/kg dose of methylprednisolone, lipid peroxidation was reduced by more than a third. After a 90-mg/kg glucocorticoid dose, an opposite effect was observed; the formation of malonyldialdehyde was actually increased by more than 55%. These data demonstrate that glucocorticoid may either decrease or increase central nervous system lipid peroxidation as a function of dose. These results have possible clinical neurological implications.
|Number of pages||4|
|State||Published - Jul 1981|
Bibliographical noteFunding Information:
Abbreviations: MP-methylprednisolone sodium succinate, MDA-malonyldialdehyde. ’ The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman and a gift of methylprednisolone sodium succinate (Solu-Medrol) from the Upjohn Co., Kalamazoo, Michigan. This research was supported by a grant to E.D.H. from the Amyotrophic Lateral Sclerosis Society of America. Address all correspondence to E.D.H.
Copyright 2014 Elsevier B.V., All rights reserved.
ASJC Scopus subject areas
- Developmental Neuroscience