Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone

J. Mark Braughler; Edward D. Hall

doi:10.1016/0006-8993(81)90311-5

Acute enhancement of spinal cord synaptosomal (Na⁺ + K⁺)-ATPase activity in cats following intravenous methylprednisolone

J. Mark Braughler, Edward D. Hall

Neuroscience

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na⁺ + K⁺)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na⁺ + K⁺)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

Original language	English
Pages (from-to)	464-469
Number of pages	6
Journal	Brain Research
Volume	219
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(81)90311-5
State	Published - Aug 31 1981

Bibliographical note

Funding Information:
Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.

Keywords

(Na + K)-ATPase
methylprednisolone
spinal cord

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(81)90311-5

Cite this

@article{b46cc93a5e8e43ce898865dfa577ffa8,

title = "Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone",

abstract = "The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.",

keywords = "(Na + K)-ATPase, methylprednisolone, spinal cord",

author = "{Mark Braughler}, J. and Hall, {Edward D.}",

note = "Funding Information: Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.",

year = "1981",

month = aug,

day = "31",

doi = "10.1016/0006-8993(81)90311-5",

language = "English",

volume = "219",

pages = "464--469",

number = "2",

}

TY - JOUR

T1 - Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone

AU - Mark Braughler, J.

AU - Hall, Edward D.

N1 - Funding Information: Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.

PY - 1981/8/31

Y1 - 1981/8/31

N2 - The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

AB - The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

KW - (Na + K)-ATPase

KW - methylprednisolone

KW - spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0019510430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019510430&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(81)90311-5

DO - 10.1016/0006-8993(81)90311-5

M3 - Article

C2 - 6266610

AN - SCOPUS:0019510430

SN - 0006-8993

VL - 219

SP - 464

EP - 469

JO - Brain Research

JF - Brain Research

IS - 2

ER -