The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.
|Number of pages||6|
|State||Published - Aug 31 1981|
Bibliographical noteFunding Information:
Methylprednisolone (sodium succinate; Solu-Medrol) was generously supplied by the UpJohn Co., Kalamazoo, Mich. The authors gratefully acknowledge the dedicated technical assistance of Mrs. Brigitte Hirst and Ms. Catherine Hyndman. This work was supported by grants to E.D.H. from the National Institute of Mental Health (MH-34111) and the Amyotrophic Lateral Sclerosis Society of America and a Biomedical Research Development Grant (RR 09026) to J.M.B.
- (Na + K)-ATPase
- spinal cord
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology