Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants

Brittnea Adcock; Sean Carpenter; John Bauer; Peter Giannone; Aric Schadler; Aftab Chishti; Mina Hanna

doi:10.1038/s41372-020-0613-5

Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants

Brittnea Adcock, Sean Carpenter, John Bauer, Peter Giannone, Aric Schadler, Aftab Chishti, Mina Hanna

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: Evaluate association between fluid balance and intraventricular hemorrhage (IVH). Study design: Retrospective review of infants <30 weeks gestation admitted to Kentucky Children’s Hospital Neonatal Intensive Care Unit. Results: Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively. Conclusion: Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.

Original language	English
Pages (from-to)	1296-1300
Number of pages	5
Journal	Journal of Perinatology
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/s41372-020-0613-5
State	Published - Sep 1 2020

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

Funding

Funders	Funder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development	R01HD070792

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-020-0613-5

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title = "Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants",

abstract = "Objective: Evaluate association between fluid balance and intraventricular hemorrhage (IVH). Study design: Retrospective review of infants <30 weeks gestation admitted to Kentucky Children{\textquoteright}s Hospital Neonatal Intensive Care Unit. Results: Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively. Conclusion: Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.",

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AU - Carpenter, Sean

AU - Bauer, John

AU - Giannone, Peter

AU - Schadler, Aric

AU - Chishti, Aftab

AU - Hanna, Mina

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AB - Objective: Evaluate association between fluid balance and intraventricular hemorrhage (IVH). Study design: Retrospective review of infants <30 weeks gestation admitted to Kentucky Children’s Hospital Neonatal Intensive Care Unit. Results: Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively. Conclusion: Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.

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Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants

Abstract

Bibliographical note

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