Acute methylphenidate administration reduces cocaine-cue attentional bias

Joseph L. Alcorn; Justin C. Strickland; Joshua A. Lile; William W. Stoops; Craig R. Rush

doi:10.1016/j.pnpbp.2020.109974

Acute methylphenidate administration reduces cocaine-cue attentional bias

Joseph L. Alcorn, Justin C. Strickland, Joshua A. Lile, William W. Stoops, Craig R. Rush

Research output: Contribution to journal › Article › peer-review

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Abstract

Mechanistic research on behavioral processes underlying substance use disorder might help identify novel targets for interventions development. Drug-related attentional bias and response inhibition deficits have received a great deal of consideration in substance use research, broadly, and cocaine use research, specifically. Studies investigating pharmacological mechanisms that may ameliorate, or further impair, these behaviors relevant to cocaine use are relatively lacking. This study evaluated the impact of acute administration of methylphenidate, a dopamine-favoring reuptake inhibitor, on both gaze-related cocaine-cue-attentional bias and cocaine-cue related disruptions in response inhibition among individuals with cocaine use disorder. Participants (N = 12; 33% female) completed a within-subject, outpatient, acute dosing study. Two sessions were completed in which methylphenidate (60 mg) or placebo were administered followed by completion of an attentional bias task using eye-tracking technology and neutral-cue and cocaine-cue response inhibition tasks. Subjective and physiological effects were also recorded. Significant cocaine cue attentional bias and response inhibition failures were observed during placebo administration. Acute methylphenidate administration reduced cocaine-cue attentional bias as measured by cocaine-cue gaze fixations (d_z = 1.04; Bayes Factor = 12.37). No statistically significant effects of methylphenidate were observed on response inhibition (Bayes Factors = 0.17–1.04). Methylphenidate produced prototypical subjective and physiological effects. Although the small sample should be considered, these findings indicate acute manipulation of dopaminergic activity reduced cue-related attentional allocation related to cocaine use disorder. Future research evaluating alternative dopaminergic agents and applications within a clinical setting are needed to determine the clinical significance of targeting this neurobehavioral mechanism.

Original language	English
Article number	109974
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	103
DOIs	https://doi.org/10.1016/j.pnpbp.2020.109974
State	Published - Dec 20 2020

Bibliographical note

Funding Information:
The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209 , T32DA035200 , R01DA025032 , R01DA032254 , R01DA033394 , R21DA035481 , R01DA036827 , R21DA034095 , R21DA035376 , R01DA036553 , R01DA033364 as well as grant 1,247,392 from the National Science Foundation . These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.

Funding Information:
The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209, T32DA035200, R01DA025032, R01DA032254, R01DA033394, R21DA035481, R01DA036827, R21DA034095, R21DA035376, R01DA036553, R01DA033364 as well as grant 1,247,392 from the National Science Foundation. These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.The authors gratefully acknowledge the staff of the University of Kentucky Laboratory of Human Behavioral Pharmacology for technical assistance and the University of Kentucky Investigational Drug Service for preparation of study medications. This study complied with all laws of the United States of America.

Publisher Copyright:
© 2020

Keywords

Attention
Behavior
Eye-tracking
Inhibitory control
Response inhibition

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2020.109974

Cite this

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title = "Acute methylphenidate administration reduces cocaine-cue attentional bias",

abstract = "Mechanistic research on behavioral processes underlying substance use disorder might help identify novel targets for interventions development. Drug-related attentional bias and response inhibition deficits have received a great deal of consideration in substance use research, broadly, and cocaine use research, specifically. Studies investigating pharmacological mechanisms that may ameliorate, or further impair, these behaviors relevant to cocaine use are relatively lacking. This study evaluated the impact of acute administration of methylphenidate, a dopamine-favoring reuptake inhibitor, on both gaze-related cocaine-cue-attentional bias and cocaine-cue related disruptions in response inhibition among individuals with cocaine use disorder. Participants (N = 12; 33% female) completed a within-subject, outpatient, acute dosing study. Two sessions were completed in which methylphenidate (60 mg) or placebo were administered followed by completion of an attentional bias task using eye-tracking technology and neutral-cue and cocaine-cue response inhibition tasks. Subjective and physiological effects were also recorded. Significant cocaine cue attentional bias and response inhibition failures were observed during placebo administration. Acute methylphenidate administration reduced cocaine-cue attentional bias as measured by cocaine-cue gaze fixations (dz = 1.04; Bayes Factor = 12.37). No statistically significant effects of methylphenidate were observed on response inhibition (Bayes Factors = 0.17–1.04). Methylphenidate produced prototypical subjective and physiological effects. Although the small sample should be considered, these findings indicate acute manipulation of dopaminergic activity reduced cue-related attentional allocation related to cocaine use disorder. Future research evaluating alternative dopaminergic agents and applications within a clinical setting are needed to determine the clinical significance of targeting this neurobehavioral mechanism.",

keywords = "Attention, Behavior, Eye-tracking, Inhibitory control, Response inhibition",

author = "Alcorn, {Joseph L.} and Strickland, {Justin C.} and Lile, {Joshua A.} and Stoops, {William W.} and Rush, {Craig R.}",

note = "Funding Information: The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209 , T32DA035200 , R01DA025032 , R01DA032254 , R01DA033394 , R21DA035481 , R01DA036827 , R21DA034095 , R21DA035376 , R01DA036553 , R01DA033364 as well as grant 1,247,392 from the National Science Foundation . These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation. Funding Information: The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209, T32DA035200, R01DA025032, R01DA032254, R01DA033394, R21DA035481, R01DA036827, R21DA034095, R21DA035376, R01DA036553, R01DA033364 as well as grant 1,247,392 from the National Science Foundation. These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.The authors gratefully acknowledge the staff of the University of Kentucky Laboratory of Human Behavioral Pharmacology for technical assistance and the University of Kentucky Investigational Drug Service for preparation of study medications. This study complied with all laws of the United States of America. Publisher Copyright: {\textcopyright} 2020",

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doi = "10.1016/j.pnpbp.2020.109974",

language = "English",

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T1 - Acute methylphenidate administration reduces cocaine-cue attentional bias

AU - Alcorn, Joseph L.

AU - Strickland, Justin C.

AU - Lile, Joshua A.

AU - Stoops, William W.

AU - Rush, Craig R.

N1 - Funding Information: The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209 , T32DA035200 , R01DA025032 , R01DA032254 , R01DA033394 , R21DA035481 , R01DA036827 , R21DA034095 , R21DA035376 , R01DA036553 , R01DA033364 as well as grant 1,247,392 from the National Science Foundation . These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation. Funding Information: The authors declare no relevant conflicts of interest. The authors gratefully acknowledge research support from the National Institute on Drug Abuse of the National Institutes of Health T32DA07209, T32DA035200, R01DA025032, R01DA032254, R01DA033394, R21DA035481, R01DA036827, R21DA034095, R21DA035376, R01DA036553, R01DA033364 as well as grant 1,247,392 from the National Science Foundation. These funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.The authors gratefully acknowledge the staff of the University of Kentucky Laboratory of Human Behavioral Pharmacology for technical assistance and the University of Kentucky Investigational Drug Service for preparation of study medications. This study complied with all laws of the United States of America. Publisher Copyright: © 2020

PY - 2020/12/20

Y1 - 2020/12/20

N2 - Mechanistic research on behavioral processes underlying substance use disorder might help identify novel targets for interventions development. Drug-related attentional bias and response inhibition deficits have received a great deal of consideration in substance use research, broadly, and cocaine use research, specifically. Studies investigating pharmacological mechanisms that may ameliorate, or further impair, these behaviors relevant to cocaine use are relatively lacking. This study evaluated the impact of acute administration of methylphenidate, a dopamine-favoring reuptake inhibitor, on both gaze-related cocaine-cue-attentional bias and cocaine-cue related disruptions in response inhibition among individuals with cocaine use disorder. Participants (N = 12; 33% female) completed a within-subject, outpatient, acute dosing study. Two sessions were completed in which methylphenidate (60 mg) or placebo were administered followed by completion of an attentional bias task using eye-tracking technology and neutral-cue and cocaine-cue response inhibition tasks. Subjective and physiological effects were also recorded. Significant cocaine cue attentional bias and response inhibition failures were observed during placebo administration. Acute methylphenidate administration reduced cocaine-cue attentional bias as measured by cocaine-cue gaze fixations (dz = 1.04; Bayes Factor = 12.37). No statistically significant effects of methylphenidate were observed on response inhibition (Bayes Factors = 0.17–1.04). Methylphenidate produced prototypical subjective and physiological effects. Although the small sample should be considered, these findings indicate acute manipulation of dopaminergic activity reduced cue-related attentional allocation related to cocaine use disorder. Future research evaluating alternative dopaminergic agents and applications within a clinical setting are needed to determine the clinical significance of targeting this neurobehavioral mechanism.

AB - Mechanistic research on behavioral processes underlying substance use disorder might help identify novel targets for interventions development. Drug-related attentional bias and response inhibition deficits have received a great deal of consideration in substance use research, broadly, and cocaine use research, specifically. Studies investigating pharmacological mechanisms that may ameliorate, or further impair, these behaviors relevant to cocaine use are relatively lacking. This study evaluated the impact of acute administration of methylphenidate, a dopamine-favoring reuptake inhibitor, on both gaze-related cocaine-cue-attentional bias and cocaine-cue related disruptions in response inhibition among individuals with cocaine use disorder. Participants (N = 12; 33% female) completed a within-subject, outpatient, acute dosing study. Two sessions were completed in which methylphenidate (60 mg) or placebo were administered followed by completion of an attentional bias task using eye-tracking technology and neutral-cue and cocaine-cue response inhibition tasks. Subjective and physiological effects were also recorded. Significant cocaine cue attentional bias and response inhibition failures were observed during placebo administration. Acute methylphenidate administration reduced cocaine-cue attentional bias as measured by cocaine-cue gaze fixations (dz = 1.04; Bayes Factor = 12.37). No statistically significant effects of methylphenidate were observed on response inhibition (Bayes Factors = 0.17–1.04). Methylphenidate produced prototypical subjective and physiological effects. Although the small sample should be considered, these findings indicate acute manipulation of dopaminergic activity reduced cue-related attentional allocation related to cocaine use disorder. Future research evaluating alternative dopaminergic agents and applications within a clinical setting are needed to determine the clinical significance of targeting this neurobehavioral mechanism.

KW - Attention

KW - Behavior

KW - Eye-tracking

KW - Inhibitory control

KW - Response inhibition

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JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

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ER -

Acute methylphenidate administration reduces cocaine-cue attentional bias

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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