Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

Michael K. McMillian, Pearlie M. Hudson, Kevin L. Simmons, Duane A. Dreyer, Jau Shyong Hong, Keith R. Pennypacker

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalMolecular Brain Research
Volume31
Issue number1-2
DOIs
StatePublished - Jul 1995

Keywords

  • AP-1
  • Adrenal
  • Chromaffin
  • Enkephalin
  • Nicotine
  • c-fos related antigen

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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