Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity . Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase  and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
|Number of pages||5|
|Journal||Molecular Brain Research|
|State||Published - Jul 1995|
- c-fos related antigen
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience