TY - JOUR
T1 - Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla
AU - McMillian, Michael K.
AU - Hudson, Pearlie M.
AU - Simmons, Kevin L.
AU - Dreyer, Duane A.
AU - Hong, Jau Shyong
AU - R. Pennypacker, Keith
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1995/7
Y1 - 1995/7
N2 - Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
AB - Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
KW - AP-1
KW - Adrenal
KW - Chromaffin
KW - Enkephalin
KW - Nicotine
KW - c-fos related antigen
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U2 - 10.1016/0169-328X(95)00053-U
DO - 10.1016/0169-328X(95)00053-U
M3 - Article
C2 - 7476031
AN - SCOPUS:0029073213
SN - 0169-328X
VL - 31
SP - 210
EP - 214
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -