Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

Michael K. McMillian; Pearlie M. Hudson; Kevin L. Simmons; Duane A. Dreyer; Jau Shyong Hong; Keith R. Pennypacker

doi:10.1016/0169-328X(95)00053-U

Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

Michael K. McMillian
, Pearlie M. Hudson
, Kevin L. Simmons
, Duane A. Dreyer
, Jau Shyong Hong
, Keith R. Pennypacker

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met⁵]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.

Original language	English
Pages (from-to)	210-214
Number of pages	5
Journal	Molecular Brain Research
Volume	31
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(95)00053-U
State	Published - Jul 1995

Keywords

AP-1
Adrenal
Chromaffin
Enkephalin
Nicotine
c-fos related antigen

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(95)00053-U

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title = "Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla",

abstract = "Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.",

keywords = "AP-1, Adrenal, Chromaffin, Enkephalin, Nicotine, c-fos related antigen",

author = "McMillian, \{Michael K.\} and Hudson, \{Pearlie M.\} and Simmons, \{Kevin L.\} and Dreyer, \{Duane A.\} and Hong, \{Jau Shyong\} and \{R. Pennypacker\}, Keith",

year = "1995",

month = jul,

doi = "10.1016/0169-328X(95)00053-U",

language = "English",

volume = "31",

pages = "210--214",

number = "1-2",

}

TY - JOUR

T1 - Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

AU - McMillian, Michael K.

AU - Hudson, Pearlie M.

AU - Simmons, Kevin L.

AU - Dreyer, Duane A.

AU - Hong, Jau Shyong

AU - R. Pennypacker, Keith

PY - 1995/7

Y1 - 1995/7

N2 - Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.

AB - Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.

KW - AP-1

KW - Adrenal

KW - Chromaffin

KW - Enkephalin

KW - Nicotine

KW - c-fos related antigen

UR - https://www.scopus.com/pages/publications/0029073213

UR - https://www.scopus.com/pages/publications/0029073213#tab=citedBy

U2 - 10.1016/0169-328X(95)00053-U

DO - 10.1016/0169-328X(95)00053-U

M3 - Article

C2 - 7476031

AN - SCOPUS:0029073213

SN - 0169-328X

VL - 31

SP - 210

EP - 214

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla

Abstract

Keywords

ASJC Scopus subject areas

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