TY - JOUR
T1 - Acute respiratory failure due to daptomycin induced eosinophilic pneumonia
AU - Kakish, Elias
AU - Wiesner, Ann M.
AU - Winstead, P. Shane
AU - Bensadoun, Eric S.
PY - 2008
Y1 - 2008
N2 - Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.
AB - Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.
KW - Acute respiratory failure
KW - Antibiotic
KW - Drug induced
KW - Eosinophilic lung disease
KW - Eosinophilic pneumonia
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U2 - 10.1016/j.rmedc.2008.07.010
DO - 10.1016/j.rmedc.2008.07.010
M3 - Article
AN - SCOPUS:52149091918
SN - 1755-0017
VL - 1
SP - 235
EP - 237
JO - Respiratory Medicine CME
JF - Respiratory Medicine CME
IS - 3
ER -