Acute respiratory failure due to daptomycin induced eosinophilic pneumonia

Elias Kakish; Ann M. Wiesner; P. Shane Winstead; Eric S. Bensadoun

doi:10.1016/j.rmedc.2008.07.010

Acute respiratory failure due to daptomycin induced eosinophilic pneumonia

Elias Kakish, Ann M. Wiesner, P. Shane Winstead, Eric S. Bensadoun

Internal Medicine

Research output: Contribution to journal › Article › peer-review

21 Citations (SciVal)

Abstract

Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.

Original language	English
Pages (from-to)	235-237
Number of pages	3
Journal	Respiratory Medicine CME
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/j.rmedc.2008.07.010
State	Published - 2008

Keywords

Acute respiratory failure
Antibiotic
Drug induced
Eosinophilic lung disease
Eosinophilic pneumonia

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.rmedc.2008.07.010

Cite this

@article{fe084524d4c44c99a2d640e17bf7867e,

title = "Acute respiratory failure due to daptomycin induced eosinophilic pneumonia",

abstract = "Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.",

keywords = "Acute respiratory failure, Antibiotic, Drug induced, Eosinophilic lung disease, Eosinophilic pneumonia",

author = "Elias Kakish and Wiesner, {Ann M.} and Winstead, {P. Shane} and Bensadoun, {Eric S.}",

year = "2008",

doi = "10.1016/j.rmedc.2008.07.010",

language = "English",

volume = "1",

pages = "235--237",

number = "3",

}

TY - JOUR

T1 - Acute respiratory failure due to daptomycin induced eosinophilic pneumonia

AU - Kakish, Elias

AU - Wiesner, Ann M.

AU - Winstead, P. Shane

AU - Bensadoun, Eric S.

PY - 2008

Y1 - 2008

N2 - Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.

AB - Daptomycin is an antibiotic that is being used with increasing frequency for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. We report a 65-year-old male patient with vertebral osteomyelitis due to MRSA who developed acute respiratory failure secondary to eosinophilic pneumonia after starting daptomycin therapy. Bronchoscopy showed a bronchoalveolar lavage (BAL) with 33% eosinophilia and the transbronchial biopsies revealed organizing pneumonia with many eosinophils. The patient responded rapidly to drug cessation and steroid therapy. Eosinophilic pneumonia is a rare but potentially serious complication of daptomycin therapy that, if recognized early, responds quickly to drug cessation and steroid therapy.

KW - Acute respiratory failure

KW - Antibiotic

KW - Drug induced

KW - Eosinophilic lung disease

KW - Eosinophilic pneumonia

UR - http://www.scopus.com/inward/record.url?scp=52149091918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52149091918&partnerID=8YFLogxK

U2 - 10.1016/j.rmedc.2008.07.010

DO - 10.1016/j.rmedc.2008.07.010

M3 - Article

AN - SCOPUS:52149091918

VL - 1

SP - 235

EP - 237

IS - 3

ER -

Acute respiratory failure due to daptomycin induced eosinophilic pneumonia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this