Acute tolerance to alcohol in at-risk binge drinkers

Mark T. Fillmore, Jessica Weafer

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Studies of the impairing effects of alcohol on behavior often show greater tolerance in heavy drinkers compared with light drinkers, suggesting a causal link between heavy consumption and tolerance. Tolerance also develops during the time course of a single drinking episode, and this "acute tolerance" might play an important role in the escalation to heavy drinking. The present study examined the development of acute tolerance to the impairing effects of alcohol on motor coordination and inhibitory control in a group of at-risk binge drinkers (n = 20) and a group of nonrisk moderate drinkers (n = 20). Participants performed the testing battery in response to placebo and a moderate dose of alcohol (0.65 g/kg) twice at comparable blood alcohol concentrations (BACs): once on the ascending limb and once on the descending limb of the blood alcohol curve. Results showed marked acute tolerance to the impairing effects of alcohol on motor coordination in the at-risk drinkers. By contrast, no recovery of motor skill was observed in the nonrisk drinkers. Regarding inhibitory control, both groups remained impaired on both the ascending and descending limbs, indicating no acute tolerance in either group. The findings suggest that at-risk binge drinkers display a faster recovery in their ability to execute versus inhibit action under alcohol. Such an "activational bias" of behavior could account for their continued alcohol consumption and impulsive behaviors while intoxicated, especially as BAC begins to decline.

Original languageEnglish
Pages (from-to)693-702
Number of pages10
JournalPsychology of Addictive Behaviors
Issue number4
StatePublished - Dec 2012


  • acute tolerance
  • alcohol
  • binge
  • inhibitory control
  • motor coordination

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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