Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia

Ann L. Coker, Rebecca B. Russell, Sharon M. Bond, Lucia Pirisi, Yong Liu, Michael Mane, Natalia Kokorina, Tsilya Gerasimova, Paul L. Hermonat

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV +. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV - /AAV + exposure, the respective aORs for HSIL and HPV + /AAV -, HPV + /AAV +, and HPV - /AAV + were 17.0, 6.9, and 3.5. AAV + was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalExperimental and Molecular Pathology
Issue number2
StatePublished - 2001

Bibliographical note

Funding Information:
This work was funded, in part, through NCI awards to Dr. Coker (R29CA57466 and R03CA73997) and an NIAID award to Dr. Hermo-nat (AI-421207).


  • Adeno-associated virus
  • Cervicalneoplasms, papillomavirus, epidemiology
  • Risk factors
  • Sexually transmitted infection
  • Women

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry


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