Rabies virus causes a fatal infection of the brain and spinal cord, accounting for approximately 59,000 deaths globally each year. Rabies postexposure prophylaxis (PEP), including both rabies immunoglobulin (RIG) and vaccination, is administered to 55,000 patients annually in the United States. With a nearly 100% case fatality rate, the optimal administration of rabies PEP cannot be understated. Updated rabies PEP guidelines issued by the World Health Organization (WHO) in 2018 recognized that local wound infiltration of RIG is the primary mechanism of protection, and the WHO now recommends only infiltration of wounds without distal intramuscular injection. We highlight potential points of failure involving wound infiltration of RIG, small-volume doses, and large-volume doses that may lead to suboptimal care and discuss implications of recent shifts toward evidence-based guidelines using wound type and RIG volumes.
Bibliographical noteFunding Information:
PBB, PA, and GTH received stipends and JTS’s employer received a stipend from Kedrion Biopharma, Inc. for participation in a human rabies immune globulin advisory board that directly supported this manuscript. JTS receives research funding from Kedrion Biopharma, Inc. and Grifols Biologics, LLC for rabies postexposure prophylaxis research. PBB has received funding from TRC Healthcare for antimicrobial stewardship content development and speaking; received speaker's honorarium from PTCe for discussion on influenza management; received speaker's honorarium from Physicians’ Education Resources, LLC for discussion on COVID‐19 monoclonal antibody therapy. HBN is an employee of Kedrion Biopharma Inc.
© 2021 Pharmacotherapy Publications, Inc.
- medication error
ASJC Scopus subject areas
- Pharmacology (medical)