AdoMet analog synthesis and utilization: current state of the art

Tyler D. Huber, Brooke R. Johnson, Jianjun Zhang, Jon S. Thorson

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

S-Adenosyl-L-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-L-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification (‘alkylrandomization’).

Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalCurrent Opinion in Biotechnology
Volume42
DOIs
StatePublished - Dec 1 2016

Bibliographical note

Funding Information:
Past and present work in the Thorson lab and the University of Kentucky Center for Pharmaceutical Research and Innovation is supported in part by NIH R37 AI52188 , NIH R01 CA203257 , NIH R24 OD21479 , the National Center for Advancing Translational Sciences ( UL1TR000117 ), the University of Kentucky College of Pharmacy and the University of Kentucky Markey Cancer Center .

Publisher Copyright:
© 2016 Elsevier Ltd

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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