Abstract
S-Adenosyl-L-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-L-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification (‘alkylrandomization’).
| Original language | English |
|---|---|
| Pages (from-to) | 189-197 |
| Number of pages | 9 |
| Journal | Current Opinion in Biotechnology |
| Volume | 42 |
| DOIs | |
| State | Published - Dec 1 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd
Funding
Past and present work in the Thorson lab and the University of Kentucky Center for Pharmaceutical Research and Innovation is supported in part by NIH R37 AI52188 , NIH R01 CA203257 , NIH R24 OD21479 , the National Center for Advancing Translational Sciences ( UL1TR000117 ), the University of Kentucky College of Pharmacy and the University of Kentucky Markey Cancer Center .
| Funders | Funder number |
|---|---|
| Center for Pharmaceutical Research and Innovation, University of Kentucky | |
| University of Kentucky | |
| National Institutes of Health (NIH) | R37 AI52188, R01 CA203257 |
| NIH Office of the Director | R24OD021479 |
| National Center for Advancing Translational Sciences (NCATS) | UL1TR000117 |
| University of Kentucky Markey Cancer Center |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering