Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?

Jiaqiao Fan; Dong Shang; Bing Han; Jianxun Song; Hailong Chen; Jin Ming Yang

doi:10.7150/thno.29035

Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?

Jiaqiao Fan, Dong Shang, Bing Han, Jianxun Song, Hailong Chen, Jin Ming Yang

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

Original language	English
Pages (from-to)	5784-5800
Number of pages	17
Journal	Theranostics
Volume	8
Issue number	20
DOIs	https://doi.org/10.7150/thno.29035
State	Published - 2018

Bibliographical note

Funding Information:
This study was supported by a grant from the National Natural Science Foundation of China (No. 81573751).

Publisher Copyright:
© Ivyspring International Publisher.

Keywords

Adoptive cell transfer
Colorectal cancer
Immunotherapy

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7150/thno.29035

Cite this

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title = "Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?",

abstract = "The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.",

keywords = "Adoptive cell transfer, Colorectal cancer, Immunotherapy",

author = "Jiaqiao Fan and Dong Shang and Bing Han and Jianxun Song and Hailong Chen and Yang, {Jin Ming}",

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T1 - Adoptive cell transfer

T2 - Is it a promising immunotherapy for colorectal cancer?

AU - Fan, Jiaqiao

AU - Shang, Dong

AU - Han, Bing

AU - Song, Jianxun

AU - Chen, Hailong

AU - Yang, Jin Ming

N1 - Funding Information: This study was supported by a grant from the National Natural Science Foundation of China (No. 81573751). Publisher Copyright: © Ivyspring International Publisher.

PY - 2018

Y1 - 2018

N2 - The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

AB - The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

KW - Adoptive cell transfer

KW - Colorectal cancer

KW - Immunotherapy

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Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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